Type II diabetes, amyloid in pancreatic islets

  • Anne Clark, University of Oxford
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Type II diabetes, amyloid in pancreatic islets. Anne Clark, University of Oxford. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.

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A photomicrograph of a section through the pancreas of a patient with Type II diabetes, showing amorphous amyloid (pink) replacing more than 80% of islet cells. The remaining beta cells are labelled brown, nuclei blue. Although more than 90% Type 2 diabetic patients have at least one islet with amyloid, not all islets are affected in all subjects. Therefore, amyloid and reduction of beta cell mass is not a determining factor for onset of Type 2 diabetes.

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