Clinical trials in neurology / Roberto J. Guiloff (ed).

London ; New York : Springer, [2001], ©2001.

xvii, 542 pages : illustrations ; 28 cm

Ch. 1. Ethical considerations -- Ch. 2. Assessment measures and clinical scales -- Ch. 3. Ethics, outcome variables and clinical scales: the clinician's point of view -- Ch. 4. The Cochrane collaboration reviews in neurology -- Ch. 5. Drug development stages -- Ch. 6. Drug regulatory requirements in the United Kingdom and Europe -- Ch. 7. Drug regulatory requirements in the United States -- Ch. 8. Quality control and data monitoring: a guide to good clinical practice -- Ch. 9. Statistical issues in clinical trials in neurology -- Ch. 10. Analysis of results: statistical principles -- Ch. 11. Survival analysis -- Ch. 12. The intention-to-treat principle for clinical trials -- Ch. 13. Statistical analysis of repeated-measures data with drop-outs -- Ch. 14. The role of meta-analyses in clinical research: uses and limitations -- Ch. 15. Outcome variables in dementia trials: conceptual and practical issues -- Ch. 16. Dementia: trial design and experience with large multicentre trials -- Ch. 17. Cerebrovascular disease: basic designs, sample sizes and pitfalls --

Ch. 18. Clinical trials in stroke prevention in North America -- Ch. 19. Cerebrovascular disease: experience within large multicentre trials -- Ch. 20. Epilepsy: ethics, outcome variables and clinical scales -- Ch. 21. Epilepsy: basic designs, sample sizes and experience with large multicentre trials -- Ch. 22. Headache: ethics, outcome variables and clinical studies -- Ch. 23. Headache: basic trial designs, sample sizes and pitfalls -- Ch. 24. Headache: experience with large multicenter trials in the treatment of migraine attacks -- Ch. 25. Parkinson's disease: outcome variables and clinical scales -- Ch. 26. Parkinson's disease: a review of drug trials -- Ch. 27. Parkinson's disease: experience with large multicentre trials -- Ch. 28. Tremor: clinical measurement of impairment, disability and handicap -- Ch. 29. Tremor: natural behaviour, trial design and physiological outcome measures -- Ch. 30. Multiple sclerosis: ethics, outcome variables and clinical scales -- Ch. 31. Multiple sclerosis: study design, sample sizes and pitfalls -- Ch. 32. Multiple sclerosis: experience with large clinical trials -- Ch. 33. Motor neurone disease: ethics, outcome variables and clinical scales -- Ch. 34. Motor neurone disease: basic designs, sample sizes and pitfalls -- Ch. 35. Motor neurone disease: experience with large multicentre trials -- Ch. 36. Peripheral neuropathies: controlled clinical trials -- Ch. 37. Peripheral neuropathies: experience with large multicentre trials -- Ch. 38. Disorders of the neuromuscular junction: outcome measures and clinical scales -- Ch. 39. Myasthenia gravis: basic designs, sample sizes and pitfalls -- Ch. 40. Myopathies: ethics, outcome variables and clinical scales -- Ch. 41. Myopathies: basic designs, sample sizes and pitfalls.

Includes bibliographical references and index.