The results of the use of refined diphtheria antitoxin, Gibson's 'Globulin preparation,' in the treatment of diphtheria / by William H. Park ; assisted by Binford Throne.

  • Park, William Hallock, 1863-1939.
Date:
1906
Catalogue details

Licence: In copyright

Credit: The results of the use of refined diphtheria antitoxin, Gibson's 'Globulin preparation,' in the treatment of diphtheria / by William H. Park ; assisted by Binford Throne. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Table I.—Results of Injecting the Mixed Antitoxic Horse Serum in Fifty Cases of Diphtheria Occurring in Children under Ten Years of Age. Case. Age in years. Deleterious efleets. Antitoxin units given. 1 X 0.9 10,000 U 2 1 3,000 s 8 1 14,000 M 4 I 1.3 15,000 M 5 X 19 5,000 S 6 I 1.5 35,000 s 7 X 1.3 10,000 u 8 X 1.3 13,500 M 9 X 1.6 10,000 10 1.7 10,000 M 11 X 1.9 10,000 M 12 1.5 7,000 13 X 1.5 10,000 S 14 X 2 17,000 JI 15 X 2 10,000 M 16 2 3,500 S 17 I 2.5 7,000 M 18 X 2.5 14,000 M 19 X 2 3,000 S 20 2 10,000 M 21 1.5 7,000 S 22 2.5 7,000 s 23 2 7,000 s 24 X 2.5 8,000 s 25 X 2.5 7,000 M 26 2.8 12,500 M 27 X 3 10,000 M 28 X 3 10,000 M 29 I 3 8,000 M 30 X 3 7,500 M 31 I 3 10,000 M 32 X 3 3,000 S 33 X 3 14,000 S 34 3 7,500 8 35 3 14,000 M 36 4 3.750 S 37 X 4 10,000 M 38 4 10.000 S 89 X 4 1 10,000 M 40 X 4 5,000 S Constitutional disturbances. Marked, 5° rise of tem- perature. Slight High temperature, due partly to pneumonia. Moderate, 2° rise of tem- perature. Rash, High temperature and marked disturbance. Moderate, with 1° rise of temperature. Masked by pneumonia having 106 tempera' ture. Moderate, with 2° rise of temperature. Marked, with 3° rise of temperature. Slight. Slight, with 1.5° rise o: temperature. Slight, with 1.5° rise of temperature. Marked, but possibly due to sepsis. Moderate, 2° temperature. Slight. Slight. Slight. Eighth day, general erythema last- ing six days. Tenth day. urticaria general. Fourteenth day, urticaria lasting five days. Eighth day, general erytherha. Sixth day, urticaria; eighth day, general erythema of very severe type. Fourth day, severe general urtica- ria lasting three days. Seventh day, severe general ery- thema. Sixth day, severe general erythema lasting three devs. Third day, morbilliform; eleventh day, severe general urticaria. Fourteenth day, erythema and urticaria general for two days. if| Second day, quite severe erythema lasting one day. Third day, very severe urticaria for two days. Third day, urticaria and erythema very severe lasting fifteen days. Extremely severe, 3°--6° for ten days. Extremely severe, 2°-4° for one week. Severe, 4° rise of tem- perature. Severe, 4° rise of tem- perature. Slight. Severe, but possibly due to pneumonia. None, except 1.50 rise of temperature. rise of Fifth day, severe urticaria for six days. Thirteenth day, severe urticaria for throe days. Twelfth day, general urticaria for two days. Sixth day, general urticaria for three days. Eighth day.morbilliform continued and intense for ten days. Fifteenth day, morbilliform contin- ued and intense for eight days. Tenth day, erythema for two days; seventeenth,second lasted six days. Seventh day, erythema for two days; twelfth day, second lasted five days. Twenty-second day, general er>'- thema. Fourteenth day, erythema for five days. Sixth day, urticaria for two days. 1 Severe, 5° rise of tem- perature for one week. Severe, for ten days 4° * rise of temperature. Very severe with 4°-7° rise of temperature for ten days. Moderate, 2° temperature. rise of Thirteenth day, severe erythema for one week until death. Thirteenth day, severe erythema lasting ten days. Eighth day, general erythema over whole body for ten days. Twelfth day, severe erythema. Sixth day, general erythema last- ing three days. Fifth day, general erythema lasting three days.