Volume 1

Gene expression / Benjamin Lewin.

  • Lewin, Benjamin.
Date:
1974-1977
Catalogue details

Licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

Credit: Gene expression / Benjamin Lewin. Source: Wellcome Collection.

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    Signals for Termination of Transcription ..... 251 termination sites recognised by rho factor ..... 252 termination in different ionic environments ..... 255 interaction of rho factor with RNA polymerase .... 260 Changes in RNA polymerase during Phage Development . . . 262 switches in early transcription of phage T4 . . . . . 262 changes in template and RNA polymerase during late T4 development 266 transcription of delayed early genes of phage A 268 7 The Lactose Operon Organization of Gene Clusters ....... 272 induction and repression ........ 272 coordinate activity of clustered genes ...... 273 structural and regulator genes . . . . . . .275 transcription of the structural genes ...... 280 Interaction of Repressor and Operator ...... 285 promotor for the structural genes ...... 285 sequence of the operator ........ 288 isolation of repressor protein ....... 290 binding of repressor to operator DNA . . . . . .291 repression of transcription ........ 297 synthesis and structure of the repressor ..... 299 Induction of Transcription at the Promotor ..... 302 glucose repression by cyclic AMP ...... 302 cyclic AMP control protein ....... 304 isolation of the lactose genes ....... 307 8 Operon Control Circuits Bacterial Operons . . . . . . . . .310 positive and negative control systems . . . . . .310 the histidine operon . . . . . . . . .316 positive-negative control of the arabinose operon .... 323 dual control of the galactose operon ...... 328 control of dispersed genes in the arginine system .... 333 complex gene clusters ........ 338 evolution of control systems ....... 343 Development of Phage A ....... 344 repression of phage DNA expression 344 isolation and function of repressor protein ..... 347 structure of the operator/promotor sites ..... 350 control of synthesis of cl repressor ...... 357 sequence of lytic development ....... 364