Further studies of experimental nephritis : some effects of diuretics / by Henry A. Christian, M.D., Boston.

  • Christian, Henry A. (Henry Asbury), 1876-1951
Date:
[1913?]
Catalogue details

Licence: In copyright

Credit: Further studies of experimental nephritis : some effects of diuretics / by Henry A. Christian, M.D., Boston. Source: Wellcome Collection.

    1/4
    leprinted from the Transactions of the Association of American Physicians, 1913 TJRTHER STUDIES OF EXPERIMENTAL NEPHRITIS; SOME EFFECTS OF DIURETICS By HENRY A. CHRISTIAN, M.D. BOSTON (From the Department of the Theory and Practice of Physic, Medical School, Harvard University) At several recent meetings of the Association of American diysicians I have reported the results of studies of experimental Lephritis carried on in the laboratory of the Department of Theory nd Practice of Physic at Harvard by myself and colleagues. During he past year, with the assistance of Drs. O’Hare, Walker, and )awson, the effect of diuretic drugs in animals suffering from acute evere nephritis produced with uranium nitrate has been investi- ;ated and in some of these animals, with the cooperation of Professor Ylin, variations in nitrogen retention have been followed. In he latter experiments the amount of non-proteid nitrogen and irea nitrogen in the blood has been determined by Dr. W. Denis n the laboratory of Biological Chemistry of Harvard University, phe general results of these studies will be given here; the details if the different experiments will be found in several papers to be Published later in the Archives of Internal Medicine. '■ In the series of experiments here reported only one animal, the rabbit, was used and only one type of nephritis produced, that following injections of uranium nitrate. A variety of drugs re¬ garded generally as having a diuretic action was employed; not ill of these, however, are considered to be diuretics in any constant sense of the word, and of some of them, such as spartein sulphate, there is much doubt that they should be considered to be diuretic drugs. These drugs were used, however, because they are often employed by clinicians to produce diuresis. They were given to