Progress in prevention.
- Date:
- 1970
- Videos
About this work
Description
Vaccination has developed considerably since Jenner's time. With a wealth of laboratory and pharmaceutical manufacturing footage this film explains the use of tissue cultures in the production of vaccines, with special reference to the production and quality of control of the Wellcome produced rubella vaccine Almovax. 2 segments.
Publication/Creation
United Kingdom : Wellcome Foundation Film Unit, 1970.
Physical description
1 encoded moving image (13.11 min.) : sound, color
Contributors
Duration
00:13:11
Copyright note
Wellcome Trust; 2009
Terms of use
Some restrictions.
CC-BY-NC
Language note
In English
Creator/production credits
Made by Hardwick Productions for the Wellcome Foundation. Narrated by Martin Jarvis, photographed by Derek Waterman, edited by Michael Foale, produced by Ann Mulligan and written and directed by John Lawrence. Filmed at the Wellcome Research Laboratories, Beckenham.
Contents
Segment 1 The Wellcome Research Laboratories in Beckenham, Kent, are seen. John Beale, the Head of Wellcome Foundation's Biological Division, describes to the camera Edward Jenner's work on vaccinations and how his discoveries have been built on by subsequent researchers. The narrator explains the history of vaccination development, including the use of chick embryos, monkey kidneys and other animal tissues and finally tissue cultures of human origin. Scientists are seen researching and developing the tissue cultures, including harvesting chick embryos. The narrator explains the history of the use of human tissue cultures in vaccinations, including the development of the WI-38 human diploid cell line developed by Dr Hayflick in the late 1950s from lung tissue. This is the culture used by Wellcome to make their rubella vaccine, Almovax. The process of developing the vaccine is shown. The cells are grown and observed. Time start: 00:00:00:00 Time end: 00:06:27:06 Length: 00:06:27:06
Segment 2 A scientist observing the tissue culture's growth explains what he is doing. Samples of the cell strain are injected into hamsters to check that no tumour-forming characteristics exist. The tissue cultures are also tested on monkey kidneys. The rubella virus is incubated. The process of producing the vaccine is shown. The raw vaccine is further tested. A scientist explains how to test the vaccine using an electron microscope. The vaccine is packaged and freeze dried. The narrator explains that this is the first vaccine that Wellcome have produced from human deployed cells, but that soon an oral polio vaccine will be produced using this method. Time start: 00:06:27:06 Time end: 00:13:11:20 Length: 00:06:44:14