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Drug interaction.

Dollery, Colin T.
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About this work


Professor Colin Dollery, Mr Matthew Conolly and Dr Donald Davies talk about drug interactions, in particular those combinations which may have a detrimental effect on the health of the patient. They discuss ways in which doctors can avoid giving out potentially dangerous drug combinations as well as combinations of drugs which counteract the effects of each other. Using a mixture of common sense, pharmacological and pharmacokinetic knowledge, Dollery and his colleagues describe ways of avoiding negative drug interactions.


London : University of London Audio-Visual Centre, 1973.

Physical description

1 encoded moving image (30.05 min.) : sound, black and white.



Copyright note

University of London

Terms of use

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

Language note

In English

Creator/production credits

Presented by Professor Colin Dollery, Mr Matthew Conolly and Dr Donald Davies. Introduced by Dr Ian Gilliland. Produced by Peter Bowen and David Sharp. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.


This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.


Segment 1 Gilliland introduces Dollery, Conolly and Davies. A film is shown of a dispensary department in a hospital, including shots of medicines on shelves and a close-up of a prescription. Dollery gives statistics for how many drugs a hospital patient is likely to receive and cautions against the prescribing of drugs which, in combination, might interact negatively. Dollery speaks to the camera and shows a diagram detailing the main sites in the body where drug interactions might occur. He then describes the physiological processes by which drugs are absorbed within the whole body. He introduces Conolly to discuss drug interactions that occur at the site of action. Time start: 00:00:00:00 Time end: 00:08:02:00 Length: 00:08:02:00
Segment 2 Conolly discusses various ways in which drugs interact with each other. He shows a diagram of a specific drug, Allopurinol, and describes the effect this particular drug has on other drugs. He discusses Insulin in some depth as Insulin is both a crucial drug for diabetics, but also a difficult drug to combine with other medications. Conolly shows diagrams relating to the interactions of some anti-depressant medications with some drugs used for the treatment of hypertension; he uses charts and diagrams to illustrate his points. Time start: 00:08:02:00 Time end: 00:16:06:20 Length: 00:08:04:20
Segment 3 Davies talks to camera. He describes how drugs cause different reactions at different receptor sites in the body. Using charts and diagrams he shows, in detail, how these reactions manifest themselves. Time start: 00:16:06:20 Time end: 00:21:24:20 Length: 00:05:18:00
Segment 4 Davies talks to camera. He describes some real case studies in which different drug combinations have had an effect on each other. He uses graphs to show how these interactions occur. He focuses in particular on the role of the liver in metabolising various medications. Time start: 00:21:24:20 Time end: 00:24:14:00 Length: 00:02:49:05
Segment 5 Dollery, Conolly and Davies are shown seated in discussion. Dollery begins and asks Conolly to provide guidance for doctors about particular situations in which drug interactions might occur. Conolly describes which drugs should be looked out for as potentially vulnerable to interactions. Dollery asks Davies to talk about the sort of non-prescribed medications that might have bad interactions with prescribed drugs. Davies gives examples of different substances that might interact badly with prescription drugs. He and Dollery discuss this in relation to many different types of drugs. Finally, Dollery sums up the main points of the lecture. Time start: 00:24:14:00 Time end: 00:30:05:16 Length: 00:05:51:16


  • English

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