Reprinted Papers: Curare

Paton's personal collection of fifty-nine reprinted papers concerning curare.

The file also contains two related pieces (to be found at the end of file part 3/3): 1. F C MacIntosh, "Pharmacological tests on trimethylaminoacetylcholine." Ts, dated 30 January, 1941. It bears the inscription: "Bill, with compliments! I missed the boat with this." 2. Newspaper cutting: O P Dinnick, obituary of Professor Guy Vourc'h (1919-1988), Anaesthesia News, 31 (February 1988), p.4. A reference to Vourc'h's MD thesis (Paris) on 'Derivatives of Methonium in Anaesthesia' is marked by Paton in pencil.

In Man and Mouse, Paton described the significance of curare to surgical practice: "Anaesthetics first dull and then remove consciousness, while both spontaneous movement (e.g. breathing and eye movements) and responses to stimuli are still present. Even with deeper anaesthesia, the response to the stimuli of abdominal surgery used to be a tightening of the muscles making the surgeon's exploration of the abdomen very difficult. Thus, for operations like that on the gall-bladder, requiring access deep under the lower ribs, it became necessary to give a lot more anaesthetic with corresponding dangers and after-effects. Curare allowed the muscles to be relaxed without having to give more anaesthetic, and the benefit in terms of access for the surgeon and of patient well-being amounted to a surgical revolution." (Paton, Man and Mouse: Animals in Medical Research, 2nd edn, Oxford, 1993, 203-4).

For the implications of the "curare-form effect" on the Cruelty to Animals Act (1876), see correspondence of the Research Defence Society for 1951-53 (E/1/5/1).

Each curare paper in the file collection bears an alpha-numerical reference (marked on the front page in ink, beginning with C). The papers comprise:

Item part 1/3:

C58: Craig, "Curariform activity and chemical structure," Chemical Reviews, 42:2 (1948), 285-410.

C64: Castillo and De Beer, "The neuromuscular blocking action of succinylcholine (diacetycholine)," Journal of Pharmacology and Experimental Therapeutics, 99 (1950), 458-64.

C625: Bulbring and Depierre, "The action of synthetic curarizing compounds on skeletal muscle and sympathetic ganglia, both normal and denervated," British Journal of Pharmacology and Chemotherapy, 4:1 (1949), 22-8.

C626: Bovet, "Curari naturali e curari di sintesi," Estratto dalla Rivista La Chimica e L'Industria, Anno XXXI (1949), 147-55.

C627: Guarino and Bovet, "L'antagonisme curare-acétylcholine et la notion de pAx," Archives Internationales de Pharmacodynamie et de Thérapie, LXXX:2-3 (1949), 159-71.

C630: Fusco, Palazzo, Chiavarelli and Bovet, "Ricerche sui curari di sintesi - Nota 1. Poliesteri aromatici di trialchiletanolammonio," Gazzetta Chimica Italiana, 78 (1948), 511-16.

C637: Coppée, "La transmission neuro-musculaire: curarisation, décurarisation et renforcement à la jonction myo-neurale," Archives Internationales de Physiologie, LIII:3/4 (1943), 327-507.

C651: Granit, Skoglund and Thesleff, "Activation of muscle spindles by succinylcholine and decamethonium: the effects of curare." Typescript (1952), including envelope with Figures.

Item part 2/3:

C652: Depierre and Funke, "Action de l'iodure de tétraméthylammonium et des iodures d'hydroxyphényltriméthylammonium sur la transmission neuro-musculaire," Compte rendus des séances de l'Académie des Sciences, t. 230 (1950), 2242-3.

C653 Depierre, "Antagonisme entre l'action curarisante...et l'action curariforme," Compte rendus des séances de l'Académie des Sciences, t. 232 (1951), 768-770.

C654: Depierre, "Propriétés décurarisantes de l'iodure de m-hydroxyphényltriméthylammonium," Compte rendus des séances de l'Académie des Sciences, t. 231 (1950), 670-2.

C655: Funke, Krucker and Depierre, "Action sur la transmission neuro-musculaire de différents sels d'ammonium quaternaires d'amino-phenols substitués," Compte rendus des séances de l'Académie des Sciences, t. 231 (1950), 2242.

C656: Funke and Depierre, "Propriétés anticurarisantes de quelques sels d'ammonium quaternaire dérivés d'aminophénols," Compte rendus des séances de l'Académie des Sciences, t.230 (1950), 245-7.

C660: Luco, Eyzaguirre and Perez, "Effects of amphetamine and cocaine on neuromuscular function," Journal of Pharmacology and Experimental Therapeutics, 93:3 (1948), 261-72.

C661: Hobson and Prescott, "Comparison of decamethonium iodide with d-tubocurarine in controlling electrically induced convulsions," Lancet (1949), 819.

C662: Gray, "Decamethonium iodide as a muscle relaxant in abdominal surgery," Lancet (1950), 253.

C663: Hewer, Lucas, Prescott and Rowbotham, "Decamethonium iodide as a muscle relaxant in anaesthesia," Lancet (1949), 817.

C664: Bovet, Depierre, Courvoisier and Lestrange, "Recherches sur les poisons curarisants de synthèse (deuxième partie)," Archives Internationales de Pharmacodynamie et de Thérapie, LXXX:2-3 (1949), 172-88.

C665: Oostende, "Sur la pharmacologie de différentes substances curarisantes," Archives Internationales de Pharmacodynamie et de Thérapie, LXXV:3-4 (1948), 419-21.

C666: Wien, "The curarising properties of R.P. 3697," Archives Internationales de Pharmacodynamie et de Therapie, LXXVII:1 (1948), 96-9.

C667: Mushin, Wien, Mason and Langston, "Curare-like actions of tri-(diethylaminoethoxy)-benzene triethyliodide," Lancet (1949), 726.

C672: Collier and Taylor, "Paralysing activity of some heterocyclic decamethylene-[xx]-bis quaternary ammonium salts," Nature, 164 (1949), 491.

C673: Taylor and Collier, "Paralysing activity of some further heterocyclic decamethylene-[xx]-bis quaternary ammonium salts," Nature, 165 (1950), 602.

C674: Gross and Cullen, "The action of curare on the smooth muscle of the small intestine and on the blood pressure," Anesthesiology, 6:3 (1945), 231-8.

C675: Blaschko, Bulbring and Chou, "Tubocurarine antagonism and inhibition of cholinesterases," British Journal of Pharmacology and Chemotherapy, 4:1 (1949), 29-32.

C676: Hobson and Prescott, "Use of d-tubocurarine chloride and thiopentone in electro-convulsion therapy," British Medical Journal, vol i (1947), 445.

C677: Prescott, Organe, and Rowbotham, "[d]-Tubocurarine chloride as an adjunct to anaesthesia," Lancet (1946), 80.

C678: Prescott, "Some aspects of the clinical pharmacology of curare," Proceedings of the Royal Society of Medicine, XL:10 (1947), 593-6.

C680: Thesleff, "The pharmacological properties of succinylcholine iodide, with particular reference to its clinical use as a muscular relaxant," Acta Physiologica Scandinavica, 26:2-3 (1952), 103-29.

C681: Thesleff, "An investigation of the muscle-relaxing action of succinyl-choline-iodide in man," Acta Physiologica Scandinavica, 25:4 (1952), 348-67.

C682: Thesleff, "An investigation of succinyl-choline-iodide in man," Acta Physiologica Scandinavica, 25:4 (1952), 368-76.

C683: Dardel and Thesleff, "Succinylcholine iodide as a muscular relaxant: a report of 500 surgical cases," Acta Chirurgica Scandinavica, 103:5 (1952), 321-36.

C684: Holmberg and Thesleff, "Succinyl-choline-iodide as a muscular relaxant in electroshock therapy," American Journal of Psychiatry, 108:11 (1952), 842-6.

C802: Foldes, Machaj, Hunt, McNall and Carberry, "Synthetic muscle relaxants in anesthesia," Journal of the American Medical Association, 150 (1952), 1559-66.

C812: Hofmann and Lembeck, "Das verhalten der ausseren augenmuskeln gegenuber curare, dekamethonium (C10) und succinylcholin (M115)," Arch. exper. Path. u. Phamakol, 216 (1952), 552-7.

C815: Philippot and Dallemagne, "Action des sels d'alkyl-triméthylammonium sur les muscles normaux et énervés du chat et du chien," Arch. exper. Path. u. Phamakol, 220 (1953), 100-15.

Item part 3/3:

C816: Dallemagne, "Les paralysants de la transmission neuro-musculaire," Annales médico-chirurgicales du Centre, IX:2 (1953), 41-9.

C817: Dallemagne and Philipott, "La déconnexion neuro-musculaire," Acta Anaesthesiologica Belgica, 2-3 (1952), 127-38.

C818: Philippot and Dallemagne, "A propos de l'action curarisante du butyl-scopolammonium (Buscopan)," Archives Internationales de Pharmacodynamie et de Thérapie, XCIII:3-4 (1953), 337-40.

C819: Brand, "A propos du mode d'action du décamethonium et de l'amyl-triméthylammonium sur la préparation isolée nerf phrénique-diaphragme du rat," Separatum Experientia, VIII:7 (1952), 273.

C820: Philippot and Dallemagne, "Les inhibiteurs de la transmission neuro-musculaire étudiés chez le chien," Separatum Experientia, VIII:7 (1952), 273.

C821: Dallemagne, "Mécanisme d'inhibition de la transmission neuro-musculaire," Anesthésie et Analgésie, IX:1 (1952), 1-18.

C822: Dallemagne and Philippot, "Synergies et antagonismes a la jonction neuro-musculaire, IV: Prostigmine et sels d'alkyl-triméthylammonium," Archives Internationales de Physiologie, LIX:4 (1951), 407-22.

C823: Denoel, Jaminet, Philippot and Dallemagne, "Contribution a l'étude chimique et pharmacodynamique des alcaloides du strychnos angolensis," Archives Internationales de Physiologie, LIX:3 (1951), 341-7.

C824: Philippot and Dallemagne, "Action des sels d'alkyl-triméthylammonium sur la transmission neuro-musculaire (note préliminaire)," Archives Internationales de Physiologie, LIX:2 (1951), 252-3.

C859: Ellis, Wnuck, De Beer and Foldes, "Modifying actions of procaine on the myoneural blocking actions of succinylcholine, decamethonium and d-tubocurarine in dogs and cats," American Journal of Physiology, 174:2 (1953), 277-82.

C921: Della Bella, Goffart and Bacq, "Action de la cystéamine et de la cystinamine sur la transmission neuro-musculaire," Archives Internationales de Physiologie, LXI:3 (1952), 449-52.

C922: Ellis, Wnuck, De Beer and Foldes, "Modifying actions of procaine on responses to myoneural blocking agents," American Journal of Physiology, 171:3 (1952), 722.

C1038: Schomburgk, "On the urari, the arrow poison of the indians of Guiana; with a description of the plant from which it is extracted," Ann & Mag Nat Hist, 17 (n.d.), 407-27. (Photocopied pages in card cover.)

C1266: Organe, "Decamethonium iodide (bistrimethylammonium decane diiodide) in anaesthesia," Lancet (1949), 773.

C1292: Presland and Palmer, "The comparative value of curarising agents with special reference to convulsion therapy," New Zealand Medical Journal, XLIX:271 (1950), 262-6.

C1294: Hunter, "The anti-curare agents," British Medical Journal, vol i (1953), 640.

C1325: Philippot and Dallemagne, "Action du dibromobenzylate de bis N-N'-(diéthylaminoéthyle) pipérazine (Isocurine) au niveau des structures cholinergiques," Archives Internationales de Pharmacodynamie et de Thérapie, XCVI:3-4 (1954), 485-6.

C1345: Heymans, Mazzella and Migliaro, "Diméthyl-tubocurarine et homéostasie de la pression artérielle," Archives Internationales de Pharmacodynamie et de Thérapie, LXXIX:2-3 (1949), 343-7.

C1353: Heymans, "Influence de la tubocurarine sur la circulation sanguine," Bulletin de L'Académie Royale de Médecine, XI:9 (1946), 286-97.

C1479: King, "Curare alkaloids, part IV. Examination of some Strychnos species from British Guiana: characterisation of diaboline, an alkaloid from Strychnos diaboli, Sandwith," Journal of the Chemical Society, 205 (1949), 955-8.

C1552: Foldes, McNall and Borrego-Hinojosa, "Succinylcholine: a new approach to muscular relaxation in anesthesiology," The New England Journal of Medicine (1952), 38-47.

C1553: Foldes, McNall, Davis, Ellis and Wnuck, "Substrate composition between procaine and succinylcholine diiodide for plasma cholinesterase," Science, 117:3041 (1953), 383-6.

C1554: Foldes, "Succinylmonocholine iodide: its enzymatic hydrolysis and neuromuscular activity," Proceedings of the Society for Experimental Biology and Medicine, 83 (1953), 187-9.

1941-1988

1 file (in 3 parts)