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Mitochondrial biogenesis.

  • Videos

About this work


The following summary appears with the cassette: "Mitochondria are unique subcellular organelles; they contain all the cyto-plasmic DNA, make messenger RNA and synthesize protein on mitoribosomes. These proteins are essential to the formation of cytochrome oxidase. Cells which lack cytochrome oxidase (anaerobic bacteria) are killed by exposure to oxygen whereas higher organisms (eukaryotes) cannot survive in its absence. Geological evidence indicates that the primitive earth was anaerobic and that the earliest life forms were also anaerobic. There is evidence that the eukaryotes may have evolved from a symbiotic relationship between a primitive anaerobe and a primitive aerobe. Drugs which block protein synthesis on mitochondria (e.g. chloramphenicol) also block synthesis of cytochrome oxidase and can be lethal to animals."


London : University of London Audio-Visual Centre, 1973.

Physical description

1 videocassette (1-inch) (27.40 min.) : sound, black and white.
1 videocassette (VHS) (27.40 min.) : sound, black and white, PAL. Original VHS used as tape master for Wellcome Film project.
1 DVD (27.40 min.) : sound, black and white, PAL.
1 videocassette (Digibeta) (27.40 min.) : sound, black and white, PAL.


This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Creator/production credits

Presented by Dr Thomas S Work. Introduced by Dr Ian Gilliland. Produced by David R Clark. Made by University of London Audio-Visual Centre. Made for British Postgraduate Medical Federation.

Copyright note

University of London



  • English

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