Influence of excess vitamin A on the sulphate metabolism of chick ectoderm grown in vitro / by H.B. Fell, Sir Edward Mellanby, and S.R. Pelc.

  • Fell, Honor B.
Date:
[1954?]
Catalogue details

Licence: In copyright

Credit: Influence of excess vitamin A on the sulphate metabolism of chick ectoderm grown in vitro / by H.B. Fell, Sir Edward Mellanby, and S.R. Pelc. Source: Wellcome Collection.

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    / little deposit over the epithelium and none over the keratin. On the other hand, in the +A explants (Figs. 2a and 2b) the connective tissue was labelled as before, but the basal cells of the epithelium had a higher content of sulphate than in the controls, and there was a dense autoradiograph over the inner secretory cells. Summary These results show that the sulphur metabolism of the presumptive epidermis of the chick converted into mucus-secreting epithelium in vitro by the presence of excess vitamin A in the culture medium is profoundly modified. In the controls, little^ sulphate is taken up by the squamous epithelium, which thus behaves like normal epidermis in vivo, whereas in the +A explants the utilization of sulphate is comparable to that of a normal mucous membrane in the body. References Bostrom, H., Odeblad, E., and Friberg, U. (1952). Arch. Biochem. Bio- phys., 38. 283. Doniach, I.. and Pelc, S. R. (1950). Brit. J. Radiol., 23, 184. Dziewiatkowski. D D., Benesch, R. E., and Benesch, R. (1949). J. bid. Chem., 178, 931. Fell, H. B., and Mellanby, E. (1953). J. Physiol., Lond., 119, 470. Gliicksmann, A., Howard, A., and Pelc, S. R. (1954). In preparation. - and Pelc, S. R. (1954). In preparation. Howard, A., and Pelc, S. R. (1951). Nature, Lond., 167, 599. Singher, H. O., and Marinelli, L. (1945). Science, 101, 414. Printed in Great Britain by Fisher, Knight & Co., Ltd., The Gainsborough Press, St. Albans.