Destruction of islets of Langerhans in Type I diabetes

  • Anne Clark, University of Oxford
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Destruction of islets of Langerhans in Type I diabetes. Anne Clark, University of Oxford. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.

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A photomicrograph of a section through the pancreas of a patient in the acute phase of Type I (early onset) diabetes. Nuclei are stained blue. The islet beta-cells have been immunolabelled for insulin (brown). The islet has been invaded by lymphocytes (small cells with large, dense nuclei) which attack and destroy the insulin-producing cells. Even though some insulin is produced this is not enough to sustain normal function.

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