Cell-mediated immune response.

London : University of London Audio-Visual Centre, 1974.

1 encoded moving image (26.48 min.) : sound, black and white.

00:26:48

University of London

Unrestricted

CC-BY-NC

Creative Commons Attribution-Non-Commercial 2.0 UK: England & Wales

In English

Presented by Professor John Turk, Institute of Basic Medical Science. Produced by Peter Bowen. Made for British Postgraduate Medical Federation. Made by University of London Audio-Visual Centre.

This video is one of around 310 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded; all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Segment 1 Turk introduces the subject, differentiating it from a previous lecture which looked at B-lymphocyte reactions; this lecture will focus on T-lymphocyte reactions. He shows a diagram detailing possible changes to bone marrow lymphocytes when affected by T-lymphocytes. Turk then shows a series of tables listing delayed hypersensitivity reactions to microbial protein antigens followed by tables comparing Arthus reactions and tuberculin antigens in terms of their reaction to T-lymphocytes. Time start: 00:00:00:00 Time end: 00:06:51:00 Length: 00:06:51:00

Segment 2 Turk uses a diagram with moveable pieces to show the mechanism of sensitisation to an invading body. He describes all immune reactions as being like a reflex arc which becomes complicated as more physiological systems become involved. Next he shows an illustration of a lymph node and a histogram of a lymph node with depleted T-lymphocytes. Time start: 00:06:51:00 Time end: 00:10:26:00 Length: 00:03:35:00

Segment 3 Turk shows an illustration of a lymph node with a proliferation of T-lymphoyctes, then autoradiographs of the same. He refers to a diagram comparing cell-mediated immunity with humoral antibody production and a graph detailing the pieaks of lymphocyte proliferation. After this, he returns to the diagram with moveable pieces and makes it more complex. Time start: 00:10:26:00 Time end: 00:17:10:00 Length: 00:06:44:00

Segment 4 Turk shows slides and graphs relating to how macrophages function in tissue culture. He describes their function in detail. Time start: 00:17:10:00 Time end: 00:20:04:00 Length: 00:02:54:00

Segment 5 Referring to a diagram of a rat as a sensitivity model, Turk shows the process of cell-mediated immune reactions step by step. After this, he returns to the earlier diagram with moveable pieces and complicates it still further. He concludes the lecture by saying that cell-mediated immunity is probably the most common allergic reaction, especially in situations such as graft rejection. Time start: 00:20:04:00 Time end: 00:26:48:20 Length: 00:06:44:20