Alternatives to animal testing : new ways in the biomedical sciences, trends and progress / edited by Christoph A. Reinhardt on behalf of the Swiss Institute for Alternatives to Animal Testing, SIAT.

Weinheim ; New York : VCH, [1994], ©1994.

xviii, 182 pages : illustrations ; 24 cm

Papers from a symposium held at the ETH, Zurich on Nov. 30, 1992, and updated to include developments through fall 1993

Looking back 33 years to Russell and Burch: the development of the concept of the threes Rs (alternatives) / A.N. Rowan -- OECD and international regulatory acceptance of the three Rs / H.M. Van Looy, H.B.W.M. Koeter -- European Centre for the Validation of Alternative Methods (ECVAM) / E. Marafante, M. Balls -- Timetable for replacing, reducing and refining animal use with the help of in vitro tests: the limulus amebocyte lysate test (LAL) as an example / O. Flint -- Fund for the replacement of animals in medical experiments (FRAME): 23 years of campaigning for the three Rs / M. Balls, J.H. Fentem -- Animal use and alternatives: developments in the Netherlands / L.F.M. van Zutphen -- RIVM Center for Alternatives to Animal Testing and the concept of the three Rs in the quality control of vaccines / C.F.M. Hendriksen -- ZEBET: three years of the National German Center for Documentation and Evaluation of Alternatives to Animal Experiments at the Federal Health Office (BGA) in Berlin / H. Spielmann, G. Grune-Wolff, M. Liebsch

(cont) Reviewed literature databank for alternatives to animal experiments-"Gelve Liste" / B. Rusche, U.G. Sauer -- SIAT research, teaching and consulting program in the area of vitro toxicology. Experimental research, screening and validation / C.A. Reinhardt -- Computer-aided drug design and the three Rs / A. Vedani -- Computer-aided programs in biomedical education / R.T. Fosse -- Alternatives to experiments with animals in medical education: a TEMPUS joint European project / M. Cervinka ... [et al.] -- Replacement of laboratory animals in the management of blood-sucking arthropods / A.E. Issmer ... [et al.] -- Maintenance of filarial cycles in the laboratory: approaches to replacing the vertebrate host / J. Rapp ... [et al.] -- Improved drug metabolizing capacity of hepatocytes co-cultured with epithelial cells and maintained in a perifusion system / R. Gebhardt -- Characterization and use of long-term liver cultures to evaluate the toxicity of cyclophosphamide or benzene to bone marrow cultures / B.A. Naughton ... [et al.]

(cont) European interlaboratory evaluation of an in vitro ocular irritation model (Skin2TM model ZK1100) using 18 chemicals and formulated products / P.W. Joller ... [et al.] -- Cellular assays for testing peritoneal dialysis bags / M. Dawson, Z. Jabar -- Position of the authorities / L. Pioda.

Includes bibliographical references and index