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HIV assembly and budding, HIV viral life cycle, illustration

  • David S. Goodsell
  • Digital Images
  • Online

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Credit: HIV assembly and budding, HIV viral life cycle, illustration. David S. Goodsell, The Scripps Research Institute. Attribution 4.0 International (CC BY 4.0)

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Watercolour and ink on paper illustration of HIV assembly and budding. Once additional viral RNA and proteins have been made inside an infected target cell (usually CD4 T cells, a type of white blood cell found in the immune system), they are assembled and packaged together into new virus particles (virions) ready for release. HIV Gag protein and gag-pol (red) form an ordered arrangement below the cell membrane (white/grey) capturing the HIV genome (yellow). Viral proteins Vpr and Vif (purple; lower middle) are also incorporated. The assembled virus then pinches off from the cell picking up cell membrane on the way to create the viral envelope. Width of image is approximately 100 nm. This image forms part of a series of illustrations which capture HIV at eight different points in the viral life cycle as it infects a cell and replicates.


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