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  • Noctinal butabarbital sodico Frosst : hipnotico inofensivo de acción rapida y sedativa : intensificador de los analgesicos, sin efectos secundarios / Charles E. Frosst & Co. ; representantes para Cuba: Distribuidora Cubana.
  • Noctinal butabarbital sodico Frosst : hipnotico inofensivo de acción rapida y sedativa : intensificador de los analgesicos, sin efectos secundarios / Charles E. Frosst & Co. ; representantes para Cuba: Distribuidora Cubana.
  • Valeriana officinalis L. Valerianaceae Valerianus, Phu, Nardus sylvestris, Setwal. Distribution: Europe. Popular herbalism attributes sedation to Valerian, but this is not mentioned by Coles (1657) or Gerard (1633) or Lobel (1576) or Lyte (1578) or Dioscorides (ex Gunther, 1959) or Fuchs (1553), where he quotes Pliny, Dioscorides and Galen, or Parkinson (1640), or Pomet (1712). The English translation of Tournefort (1719-1730) covers a whole page of the uses of all the different valerians, but never mentions sedation or treating anxiety. Quincy (1718) does not mention it. Because it was used in epilepsy, for which Woodville (1792) says it was useless, Haller, in his Historia stirpium indegenarum Helvetae inchoatae (1768) advocates it for those with irritability of the nervous system, as does Thomson's London Dispensatory (1811) although he lists it as an 'antispasmodic and stimulant' and for inducing menstruation. Lindley (1838) notes (as many did) that the roots smell terrible and that this makes cats excited, and in man, in large doses, induce 'scintillations, agitation and even convulsions' so used in asthenic fever, epilepsy, chorea, hysteria and as an antihelminthic.' Fluckiger & Hanbury (1879) give a wonderful account of the history of its names, but give its use as 'stimulant and antispasmodic' as do Barton & Castle (1877). but by 1936 (Martindale's Extra Pharmacopoeia) its only use was 'Given in hysterical and neurotic conditions as a sedative. Its action has been attributed to its unpleasant smell'. The European Medicines Agency (2006) approves its use as a traditional herbal medicine for mild anxiety and sleeplessness for up to 4 weeks. Despite what is written continuously about its use in ancient Greece and Rome, the only reason for its use has been because it was thought, for a brief while, to be good for epilepsy and therefore might deal with persons of a nervous disposition because of its foul smell. It has been suggested that even its Greek name, 'Phu' came from the expression of disgust which is made when one sniffs an unpleasant odour. For 1,800 years, before the last century, no-one had thought it sedative. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Libellus, quo demonstratur: colchici autumnalis radicem non solum tuto posse exhiberi hominibus, sed et ejus usu interno curari quandoque morbos difficillimos, qui aliis remediis non cedunt / [Anton Störck].
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Alphabeti verè naturalis Hebraici brevissima delineatio. Quae simul methodum suppeditat, juxta quam qui surdi nati sunt sic informari possunt, ut non alios saltem loquentes intelligant, sed et ipsi ad sermonis usum perveniant / In lucem edita à F.M.B. ab Helmont.
  • Alphabeti verè naturalis Hebraici brevissima delineatio. Quae simul methodum suppeditat, juxta quam qui surdi nati sunt sic informari possunt, ut non alios saltem loquentes intelligant, sed et ipsi ad sermonis usum perveniant / In lucem edita à F.M.B. ab Helmont.
  • Alphabeti verè naturalis Hebraici brevissima delineatio. Quae simul methodum suppeditat, juxta quam qui surdi nati sunt sic informari possunt, ut non alios saltem loquentes intelligant, sed et ipsi ad sermonis usum perveniant / In lucem edita à F.M.B. ab Helmont.
  • Alphabeti verè naturalis Hebraici brevissima delineatio. Quae simul methodum suppeditat, juxta quam qui surdi nati sunt sic informari possunt, ut non alios saltem loquentes intelligant, sed et ipsi ad sermonis usum perveniant / In lucem edita à F.M.B. ab Helmont.
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • Petri Borelli ... Historiarum, et observationum medicophysicarum, centuriae IV. In quibus non solum multa utilia, sed & rara, stupenda ac inaudita continentur / Accesserunt D. Isaaci Cattieri ... observationes medicinales rarae Dom. Borello communicatae: et Renati Cartesii vita eodem P. Borello authore. Quae omnia nunc primum in lucem prodeunt.
  • Emblemata Nicolai Reusneri ic. partim ethica, et physica : partim vero historica, ac hieroglyphica, sed ad virtutis, morumque doctrinam omnia ingeniose traducta: et in quatuor libros digesta, cum symbolis ac inscriptionibus illustrium ac clarorum virorum. Quibus agalmatum, sive emblematum sacrorum liber unus superadditus / Ex recensione Ieremiae Reusneri Leonini.
  • Emblemata Nicolai Reusneri ic. partim ethica, et physica : partim vero historica, ac hieroglyphica, sed ad virtutis, morumque doctrinam omnia ingeniose traducta: et in quatuor libros digesta, cum symbolis ac inscriptionibus illustrium ac clarorum virorum. Quibus agalmatum, sive emblematum sacrorum liber unus superadditus / Ex recensione Ieremiae Reusneri Leonini.
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].
  • De re metallica libri XII. Quibus officia, instrumenta, machinae, ac omnia denique ad metallicam spectantia, non modo luculentissime describuntur, sed et per effigies ... adjunctis latinis germanicisque appellationibu ita ob oculos ponuntur, ut clarius tradi non possint. Ejusdem de animantibus subterraneis liber ... Cum indicibus diversis / [Georg Agricola].