Wellcome uses cookies.

Read our policy
Skip to main content
264 results
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Surface potential of calmodulin - ligand
  • Certain necessary directions, as well for the cure of the plague, as for preventing the infection with many easie medicines of small charge, very profitable to His Majesties subjects / Set downe by the Colledge of Physicians by the Kings Majesties speciall command. With sundry orders thought meet by His Majestie, and his Privie Councell for prevention of the plague. Also certaine select statutes ... Together with His Majesties proclamation for further direction therein and a decree in Starre-Chamber. Concerning buildings and in-mates.
  • Orders, thought meete by Her Maiestie, and her privie Councell, to be executed throughout the counties of this realme, in such townes, villages, and other places, as are, or may be hereafter infected with the plague ... Also, an advise set downe ... by the best learned in physicke ... contayning sundry good rules and easie medicines.
  • Orders, thought meete by Her Maiestie, and her priuie Councell, to be executed throughout the counties of this realme, in such townes, villages, and other places, as are, or may be hereafter infected with the plague, for the stay of further increase of the same. Also, an aduise set downe vpon Her Maiesties expresse commaundement, by the best learned in physicke within this realme, contayning sundry good rules and easie medicines. Without charge to the meaner sort of people, aswell for the preseruation of her good subiects from the plague before infection, as for the curing and ordring of them after they shalbe infected.
  • Angiogenin - Placental ribonuclease inhibitor complex
  • Exeat signs of the Ding army. Four carved and painted signs.
  • Exeat signs of the Ding army. Four carved and painted signs.
  • Cada inyección de Neosepticemine : provoca descenso en la temperatura sin "choc" ni reacción / Laboratorios Brunschwig & Co.
  • Cada inyección de Neosepticemine : provoca descenso en la temperatura sin "choc" ni reacción / Laboratorios Brunschwig & Co.
  • Murine pancreas, SPIM
  • A Catalogue of Surgical Instruments, by Arnold & Sons
  • DNA sequence of CCR5 Delta 32 gene mutation
  • DNA sequence of CCR5 Delta 32 gene mutation
  • DNA sequence of CCR5 Delta 32 gene mutation
  • A lady asks a pharmacist about his enlargening potion; he displays the bump on his head as proof of its efficacy. Process print after a wood engraving.
  • Harmless coloring for food stuffs : chocolate brown / A. Boake, Roberts & Co. Ltd.
  • Harmless coloring for food stuffs : chocolate brown / A. Boake, Roberts & Co. Ltd.
  • A poor technique for radiotherapy of a cat
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Modo e ordine securo da preservarse e curarse dal pestifero morbo: novamente aggregato / [Giovanni Antonio Bassino].
  • Trattato di vaccinazione con osservazioni sul giavardo e vajuolo pecorino / Del dottore Luigi Sacco ... Con quattro tavole miniate.
  • Trattato di vaccinazione con osservazioni sul giavardo e vajuolo pecorino / Del dottore Luigi Sacco ... Con quattro tavole miniate.