Conference : recent developments in prevention and therapy through Maharishi ayur-veda towards a disease-free society : new approaches to the prevention and treatment of heart disease, chronic disorders, cancer, AIDS : Royal College of Physicians, London, Monday 17 October 1988 / World Medical Association for Perfect Health - Great Britain.

Euphorbia milii Des Moul. Euphorbiaceae. Crown of Thorns - so called because of its very spiny stems. Distribution: Madagascar. The latex contains a copper-containing amine oxidase, a lectin, lipase, peroxidase, and a diamine oxidase. In vitro the latex is synergistic with ketoconazole against Candida albicans (thrush). All Euphorbia have a toxic white latex, and in Europe this has been used as a folk remedy to treat warts. It can cause skin allergies and the smoke from burning them is toxic. the genus named for Euphorbus (fl. circa 10 BC – 20 AD), the Greek physician to the Berber King Juba II (c. 50 BC – 23 AD) of Numidia, Euphorbia milii is one of the tropical spurges, with fierce, cactus-like spines, grown as a house plant. The sap of spurges is used in folk medicine for treating warts (not very effective), and, historically, as a purgative - the word spurge being derived from the French word for purgation. The sap (probably dried) was administered inside a fig because it is so corrosive that it would otherwise burn the mouth and oesophagus – a technique used today, rather more subtly, with ‘enteric coated’ medications. The sap contains a potential anti-leukaemic chemical, lasiodoplin, and is also used in drainage ditches to kill the snails which carry the parasitic trematode which causes fasciolaris. It does not kill the fish. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Catharanthus roseus (L.)G.Don Apocynaceae. Madagascar Periwinkle Distribution: Madagascar. It is the source of vincristine and vinblastine, which impair cell multiplication by interfering with microtubule assembly, causing metaphase arrest and are effective medications for leukaemias, lymphomas and some solid tumours. The mortality from childhood leukaemia fell from 100% to 30% once it was introduced - not a drug that could ethically be tested by double-blind trials. These chemicals were initially discovered by investigators in 1958 who were looking for cures for diabetes so tested this plant which was being used in the West Indies to reduce blood sugar levels. There are 70 different alkaloids present in this plant, and some - catharanthine, leurosine sulphate, lochnerine, tetrahydroalstonine, vindoline and vindolinine - lower blood sugar levels. However, the toxicity of this plant is such that this is not a plant to try at home for diabetic management. The vincristine content of the plant is 0.0003%, so two kilograms of leaf are required to produce sufficient vincristine for a single course of treatment for a child (6gm). Fortunately it is a vigorous weed and easy to grow in the tropics. Artificial synthesis has now been achieved. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Eranthis hyemalis Salisb. Ranunculaceae Winter Aconite Distribution: Europe. The reason it was called Winter aconite and linked to Aconitum napellus as being just as poisonous is because plants were classified according to leaf shape in the 16th century. L'Obel's Stirpium adversaria nova (1571) and Plantarum seu stirpium historia (1576) (with a full page illustration on page 384 showing Eranthis and Aconitum together) along with the knowledge that related plants have similar medical properties caused the belief that Eranthis are as poisonous as Aconitum. They are both in Ranunculaceae and while Eranthis (like all Ranunculaceae)is toxic if eaten, it does not contain the same chemicals as Aconitum. Caesalpino (Ekphrasis, 1616) pointed out the error in classifying according to leaf shape and recommended flower shape. It contains pharmacologically interesting chemicals such as khellin, also present in Ammi visnaga. This is a vasodilator but quite toxic, but can be converted into khellin analogues such as sodium cromoglicate – used as a prophylaxis against asthma attacks – and amiodarone which has anti-arrhythmia actions so is used for atrial fibrillation and other arrhythmias. It is endangered and protected in the wild (Croatia) because of over-collecting for horticulture. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Eranthis hyemalis Salisb. Ranunculaceae Winter Aconite Distribution: Europe. The reason it was called Winter aconite and linked to Aconitum napellus as being just as poisonous is because plants were classified according to leaf shape in the 16th century. L'Obel's 'Stirpium adversaria nova' published in 1571 and 'Plantarum seu stirpium historia' published 1576 (with a full page illustration on page 384 showing Eranthis and Aconitum together) along with the knowledge that related plants have similar medical properties caused the belief that Eranthis are as poisonous as Aconitum. They are both in Ranunculaceae and while Eranthis (like all Ranunculaceae) is toxic if eaten, it does not contain the same chemicals as Aconitum. Caesalpino (Ekphrasis, 1616) pointed out the error in classifying according to leaf shape and recommended flower shape. It contains pharmacologically interesting chemicals such as khellin, also present in Ammi visnaga. This is a vasodilator but quite toxic, which can be converted into khellin analogues such as sodium cromoglicate – used as a prophylaxis against asthma attacks – and amiodarone which has anti-arrhythmia actions so is used for atrial fibrillation and other arrhythmias. It is endangered and protected in the wild (Croatia) because of over-collecting for horticulture. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

The Sir Jamsetjee hospital, Grant medical college, and surrounding grounds, Bombay. Wood engraving after H. Hinton.

King's College (London) Medical Faculty Rugby Team: group portrait of winning team with cup for the 1925-1926 season. Photograph, 1926.

Royal College of Physicians, Warwick Lane, London: the courtyard. Engraving, 1668/1697.

9 "Tabloid" medicine Cases used in Africa

Veronicastrum virginicum 'Pink Glow'

Two trees being cultivated by doctors; symbolising the differences claimed by James Morison between the 'organic' and his 'hygeist' approached to health. Lithograph, c. 1835.

A horse-drawn hearse pulls away from a doctor's; representing the dire state of the medical establishment according to James Morison, pill-vendor and self-styled 'Hygeian'. Lithograph, c. 1848.

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