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57 results
  • Movie of necrotic cell death
  • Cell death in limb bud
  • Cell death around scleral blood vessels
  • Cell death in limb bud of a webbed foot
  • Ugolino, his sons and grandsons in a cell facing death by starvation. Engraving by A. Raimbach after Sir J. Reynolds.
  • A man condemned to death visited by his family in his prison cell on the day of his execution. Wood engraving by P. Jonnard after M. Munkácsy.
  • Lathyrus vernus (L.)Bernh. Papilionaceae previously Orobus vernus L. (Linnaeus, 1753) Spring vetchling. Distribution: Europe to Siberia. The seeds of several Lathyrus species are toxic, and when eaten cause a condition called lathyrism. The chemical diaminoproprionic acid in the seeds causes paralysis, spinal cord damage, aortic aneurysm, due to poisoning of mitochondria causing cell death. Occurs where food crops are contaminated by Lathyrus plants or where it is eaten as a 'famine food' when no other food is available. It is the Orobus sylvaticus purpureus vernus of Bauhin (1671) and Orobus sylvaticus angustifolius of Parkinson (1640) - who records that country folk had no uses for it. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Lathyrus vernus (L.)Bernh. Papilionaceae previously Orobus vernus L. (Linnaeus, 1753) Spring vetchling. Distribution: Europe to Siberia. The seeds of several Lathyrus species are toxic, and when eaten cause a condition called lathyrism. The chemical diaminoproprionic acid in the seeds causes paralysis, spinal cord damage, aortic aneurysm, due to poisoning of mitochondria causing cell death. Occurs where food crops are contaminated by Lathyrus plants or where it is eaten as a 'famine food' when no other food is available. It is the Orobus sylvaticus purpureus vernus of Bauhin (1671) and Orobus sylvaticus angustifolius of Parkinson (1640) - who records that country folk had no uses for it. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Senna corymbosa (Lam.)H.S.Irwin&Barneby Caesalpinaceae. Argentine Senna. Distribution: Argentine (other species from Europe). This beautiful shrub that flowers from midsummer until the frosts of winter, is the source of one of the best known of all herbal medicines – Senokot (and senna pods and senna tea), introduced to European medicine (as Senna alexandrina from Egypt) by the Arabians. Every part of the plant contains anthraquinones which, if taken internally, act as a powerful laxative to treat constipation by stimulating the nerve cells of the large bowel. Gerard (1633) notes ‘it is a singular purging medicine’ with over a page on its uses. When used regularly the nerves to the large bowel may be destroyed, leaving a permanently dilated large bowel that never functions properly again. This is a plant which causes the condition it treats to become permanent. Additionally, with prolonged use, the lining of the bowel turns black, serum potassium levels may fall, resulting in cardiac irregularities and sometimes death. Coma, neuropathy and hepatitis have also been reported. It is advertised on television (the actor involved is seen to be depressed and bloated until she takes Senokot, after which she is happy - Hippocrates would have attributed this antidepressant effect to the plant's ability to purge her of the black melancholic humour present in her bowel motions). It is available without prescription or health warning against long-term use. What do you think? Lyte (1578) recommends it strongly for depression, but one might claim to be cured rather than take it again. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Senna corymbosa (Lam.)H.S.Irwin&Barneby Caesalpinaceae. Argentine Senna. Distribution: Argentine (other species from Europe). This beautiful shrub that flowers from midsummer until the frosts of winter, is the source of one of the best known of all herbal medicines – Senokot (and senna pods and senna tea), introduced to European medicine (as Senna alexandrina from Egypt) by the Arabians. Every part of the plant contains anthraquinones which, if taken internally, act as a powerful laxative to treat constipation by stimulating the nerve cells of the large bowel. Gerard (1633) notes ‘it is a singular purging medicine’ with over a page on its uses. When used regularly the nerves to the large bowel may be destroyed, leaving a permanently dilated large bowel that never functions properly again. This is a plant which causes the condition it treats to become permanent. Additionally, with prolonged use, the lining of the bowel turns black, serum potassium levels may fall, resulting in cardiac irregularities and sometimes death. Coma, neuropathy and hepatitis have also been reported. It is advertised on television (the actor involved is seen to be depressed and bloated until she takes Senokot, after which she is happy - Hippocrates would have attributed this antidepressant effect to the plant's ability to purge her of the black melancholic humour present in her bowel motions). It is available without prescription or health warning against long-term use. What do you think? Lyte (1578) recommends it strongly for depression, but one might claim to be cured rather than take it again. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Apoptotic cells in a mouse blastocyst
  • Apoptotic cells
  • Apoptosis in an isolated ovarian follicle
  • Lymphocytes and apoptotic plasma cells
  • Apoptosing plasma cells and collagen
  • Focus of plasma cell apoptosis
  • DNA sequence of CCR5 Delta 32 gene mutation
  • DNA sequence of CCR5 Delta 32 gene mutation
  • DNA sequence of CCR5 Delta 32 gene mutation
  • Breast cancer cells
  • Breast cancer cells
  • Developing chick limb
  • Movie of apoptosis, confocal
  • Rectum: HIV-related enteropathy
  • HeLa cells expressing the protein survivin
  • Stages of limb development
  • The family of Jean Calas sit listening to Alexandre Lavaysse reading a letter from Calas. Engraving by J.B. Delafosse after L.C. De Carmontelle.
  • Lepromatous leprosy: local (acute) exacerbation reaction