Wellcome uses cookies.

Read our policy
Wellcome Collection homepage
All
Stories
Images
Catalogue
Events
86 results
  • Human oral squamous cell carcinoma cell, SEM
  • Human oral squamous cell carcinoma cell, SEM
  • Human oral squamous cell carcinoma cell, SEM
  • Human oral squamous cell carcinoma cell, SEM
  • Patient who had a recurrent carcinoma of the right breast
  • Patient who had a recurrent carcinoma of the right breast
  • A severely diseased penis showing symptoms of carcinoma. Watercolour with chalk by C. D'Alton, 1865.
  • Cell from a squamous cell carcinoma cell line. It has been frozen and split open to reveal its nucleus.
  • Lung cancer cell. This image shows a single cell grown from a culture of lung epithelial carcinoma (cancer) cells. The purple area shows blebbing.
  • Liver of a DEN (Diethylnitrosamine)-treated rat. DEN is a toxic chemical which quickly induces liver cirrhosis followed by HCC (Hepatocellular carcinoma, a primary liver cancer). Cirrhosis is an end result of fibrosis, the scarring of liver tissue. Fibrosis is caused by the overproduction of collagen, a component of the connective tissue forming the liver. To grade the amount of cirrhosis present in a liver sample, collagen is made visible using the dye sirius red. Under polarized light, collagen is observed as the golden to red color as shown in this image.
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • A diseased duodenum. Chromolithograph by W. Gummelt, ca. 1897.
  • A diseased duodenum, with a detail showing cells as seen through a microscope. Chromolithograph by W. Gummelt, ca. 1897.
  • A diseased stomach, showing signs of cancer. Chromolithograph by W. Gummelt, ca. 1897.
  • A cancerous lung and bronchi. Chromolithograph by W. Gummelt, ca. 1897.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Pathological anatomy : illustrations of the elementary forms of disease / By Robert Carswell.
  • Noxyflex : anti-bacterial, anti-fungal.
  • Noxyflex : anti-bacterial, anti-fungal.