Sempervivum tectorum L. Crassulaceae Houseleek, Senegreene Distribution: Europe. Sempervivum means 'live forever', tectorum means 'roof', and was apparently grown on house roofs to protect against lightning. Lyte (1578 distinguishes Stonecrops (Sedum) from Sengreene (Sempervivum) for he advises the latter, alone or mixed with barley meal, applied topically to burns, scalds, St Anthony's fire [erysipelas] , ulcers and sores, will cure them and sore eyes. Apropos of stonecrops (Sedum), he describes the redness and blistering that the sap has on bare skin, and how it is good for poisons for if taken with vinegar by mouth it causes vomiting, but only safe to do so in strong people. He seems fairly confused as to which is which. Not approved by the European Medicines Agency for Traditional Herbal Medicinal use. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Epimedium pubescens Maxim. Berberidaceae. Horny (sic) Goat Weed. Distribution: China. Marketed as an aphrodisiac, with the ability to act like sildenafil and for osteoporosis. Side effects reported include dizziness, dry mouth, vomiting and cardiac irregularity. It is not listed in Wiart (2006) or Wichtl (1994). Its reputation began, apparently, when a Chinese farmer observed increased sexual activity in his goats after they had been eating Epimedium. Given the enormous profits made by medicines such as sildenafil, it is indicative of its therapeutic value that it has not been taken up by a pharmaceutical company. Poor absorption from the gut and lack of information on toxicity may be responsible. It is not licensed for sale in the UK as a Traditional Herbal Remedy (Traditional Herbal Medicines Registration, January 2013) and has not been assessed or approved by the European Medicines Agency's Committee on Herbal Medicinal Products (HMPC). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Gardenia jasminoides J.Ellis Rubiaceae. Cape jasmine - as erroneously believed to have come from South Africa. Distribution: China. Named for Dr Alexander Garden FRS (1730-1791) Scottish-born physician and naturalist who lived in Charles Town, South Carolina, and corresponded with Linnaeus and many of the botanists of his era. The fruits are used in China both as a source of a yellow dye, and for various unsubstantiated medicinal uses. Other species of Gardenia are found in tropical Africa and the roots and leaves have all manner of putative uses. Gardenia tenuifolia is used as an aphrodisiac, for rickets, diarrhoea, leprosy, gall bladder problems, toothache, liver complaints, diabetes, hypertension, malaria and abdominal complaints. It causes violent vomiting and diarrhoea. It, and other species, are used to poison arrows and to poison fish. Some native, muthi medicine, healers regard Gardenia as a ‘last chance’ medicine, given to patients when all else fails – the patient either dies or recovers (Neuwinger, 1996). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Pulsatilla vulgaris Mill. Ranunculaceae Distribution: Europe. Lindley (1838) and Woodville (1790) knew this as Anemone pulsatilla, the common name being Pasque (Easter) Flower. At the end of the 18th century it was recommended for blindness, cataracts, syphilis, strokes and much more, treatments which, as was clear to physicians at the time, were valueless. Gerard (1633) writes: ‘They serve only for the adorning of gardens and garlands, being floures of great beauty’. It is in the buttercup family, Ranunculaceae, all members of which are poisonous. It was recommended, by mouth, for ‘obstinate case of taenia’ (tapeworms). One hopes it was more toxic to the worm than the patient. Flowers with a central disc and radiating florets were regarded as being good for eye complaints under the Doctrine of Signatures. Porta (1588) writes (translated): ‘Argemone [Papaver argemone], and anemone, have flowers of this shape, from this they cure ulcers and cloudiness of the cornea’. There were occupational diseases even before there were words like pneumoconiosis, and Lindley writes that ‘the powder of the root causes itching of the eyes, colic and vomiting, if in pulverising it the operator do not avoid the fine dust which is driven up.’ Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Pulsatilla vulgaris Mill. Ranunculaceae. Pasque flower. Distribution: Europe. Lindley (1838) and Woodville (1790) knew this as Anemone pulsatilla, the common name being Pasque (Easter) Flower. At the end of the 18th century it was recommended for blindness, cataracts, syphilis, strokes and much more, treatments which, as was clear to physicians at the time, were valueless. Gerard (1633) writes: ‘They serve only for the adorning of gardens and garlands, being floures of great beauty’. It is in the buttercup family, Ranunculaceae, all members of which are poisonous. It was recommended, by mouth, for ‘obstinate case of taenia’ (tapeworms). One hopes it was more toxic to the worm than the patient. Flowers with a central disc and radiating florets were regarded as being good for eye complaints under the Doctrine of Signatures. Porta (1588) writes (translated): ‘Argemone [Papaver argemone], and anemone, have flowers of this shape, from this they cure ulcers and cloudiness of the cornea’. There were occupational diseases even before there were words like pneumoconiosis, and Lindley writes that ‘the powder of the root causes itching of the eyes, colic and vomiting, if in pulverising it the operator do not avoid the fine dust which is driven up.’ Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Pulsatilla vulgaris Mill. Ranunculaceae Pasque flower. Distribution: Europe. Lindley (1838) and Woodville (1790) knew this as Anemone pulsatilla, the common name being Pasque (Easter) Flower. At the end of the 18th century it was recommended for blindness, cataracts, syphilis, strokes and much more, treatments which, as was clear to physicians at the time, were valueless. Gerard (1633) writes: ‘They serve only for the adorning of gardens and garlands, being floures of great beauty’. It is in the buttercup family, Ranunculaceae, all members of which are poisonous. It was recommended, by mouth, for ‘obstinate case of taenia’ (tapeworms). One hopes it was more toxic to the worm than the patient. Flowers with a central disc and radiating florets were regarded as being good for eye complaints under the Doctrine of Signatures. Porta (1588) writes (translated): ‘Argemone [Papaver argemone], and anemone, have flowers of this shape, from this they cure ulcers and cloudiness of the cornea’. There were occupational diseases even before there were words like pneumoconiosis, and Lindley writes that ‘the powder of the root causes itching of the eyes, colic and vomiting, if in pulverising it the operator do not avoid the fine dust which is driven up.’ Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Asphodeline lutea Rchb. Yellow asphodel, King's spear, Hastula regia. Hardy rhizomatous perennial. Distribution Mediterranean and Caucasus. It is the flower of the dead, as Homer writes that it carpets an area in the gloomy darkness of the underworld (Hades), in Greek mythology where the souls of the dead are found. However this may be a misinterpretation of the Greek where 'Asphodel' has been read instead of 'ash-filled'. In the etymology of flower names, it is suggested that the yellow 'daffodil' is a corruption of French or Flemish 'de asphodel' (both ex Steve Reece, 2007). An Aristotelian epigram, refers to it growing on tombs: 'On my back I hold mallow and many-rooted asphodel ...' The asphodel was sacred to Persephone, goddess of the underworld, who was seized and wed by Hades, god of the underworld, and taken to his kingdom. Her disappearance brings the winter, and her reappearance each year, the spring. The only reliable source of information about its early medical uses is, probably, Dioscorides although the plant in his De Materia Medica may be A. ramosus or A. albus. He gives its properties as diuretic, induces menses, good for coughs and convulsions, an antidote to snake bite, applied as a poultice for sores of all sorts, and in compounds for eye, ear and tooth pains, and to cure alopecia and vitiligo, but induces diarrhoea and vomiting and is an anti-aphrodisiac. Fuchs (1542), as Ruel’s commentaries (1543) note, makes a big mistake as he has Lilium martagon as his concept of A. luteus. Ruel only illustrates its leaves and roots, calling it Hastula regia (Latin for King’s spear) but Matthiolus's Commentaries (1569 edition) has a reasonable woodcut also as Hastula regia (1569). Dodoen's Cruydeboeck (1556) does not mention or illustrate Asphodelus luteus. L'Escluse's French translation Histoire des Plantes (1557) follows the Cruydeboeck. Dodoen's Latin translation Stirpium Historia Pemptades Sex (1583) adds A. luteus with text and woodcut, with no uses. Henry Lyte's (1578) translation illustrates Asphodelus luteus as Asphodeli tertia species and 'Yellow affodyl' (vide etymology of 'daffodil') and also does not describe any uses for it. Gerard's translation The Herbal (1597 and 1633) continues the muddle and does not give any uses for this plant. Parkinson's comments (1640) on the lack of medicinal properties of asphodels, refer to quite different plants coming from wet areas in Lancashire, Scotland and Norway . He calls them pseudoasphodelus major and minor which he writes are called Asphodelus luteus palustris by Dodoens, and not 'King's Spear' which he illustrates with a good woodcut of A. luteus and calls it Asphodelus luteus minor. Once herbals started to be written in northern Europe, the knowledge of the arid loving, Asphodelus luteus of south east Europe was lost. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Norovirus - colour-enhanced

The question "Waiter, where can I have a puke?" advertising a quiz on alcohol abuse. Colour lithograph by Nationaal Instituut voor Gezondheidsbevordering en Ziektepreventie, 2000.

TEM of Norovirus

A woman holding a man's head while he is sick into a bowl. Coloured lithograph.

A male patient is hanging by his feet from an apparatus, a large worm (?) is passing from his mouth into a bowl, assisted by a surgeon and two assistants. Process print after a woodcut, 1497.

Usos aceptados por el consejo de quimica y farmacia de la Asociación Medica Americana de la Dramamine ... / G.D. Searle & Co. ; distribuído por: Enrique Ferreyros y Cia., S.A.

TEM of Noroviruses

Negligence and idleness represented as a dishevelled woman surrounded by people gambling, drinking, fighting etc. Engraving attributed to P. Galle.

Nautisan : bei nervösem Erbrechen der Säuglinge, Pertussis, Chorea, azetonämischem Erbrechen usw.

The new therapy bulletin. Bulletin no. 2 / Clinical Department of the Chattanooga Vibrator Instrument Company.

The rulers of Europe as doctors prescribing remedies for Empress Maria Theresa. Etching and letterpress, 1742.

Plegicil : neurolplégico : gran actividad, dosis terapeuticas bajas / Laboratoires Clin-Comar ; hecho en Mexico por: Labfarmex, S.A.

Visitors to the gardens of the Horticultural Society of London in Chiswick, among whom is a man who rushes off believing he has an attack of the cholera. Coloured etching by H. Heath, 1831.

Two men playing backgammon on a barrel-table as others watch and smoke. Mezzotint after E. van Heemskirk.

Neuroplagico Largactil : lo que hay que saber del: Largactil ... / marcas Rhône Poulenc Specia.

Neuropléjico Largactil : lo que es preciso saber del: Largactil ... / Société parisienne d'expansion chimique.

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