The breast cancer pink ribbon emblem representing the word 'pink': mobile mammography units in Kenya. Colour lithograph by Safaricom Foundation, ca. 2007.

Elizabeth Hopkins of Oxford, showing a breast with cancer which was removed by Sir William Read. Engraving by M. Burghers, ca. 1700.

Left, methods of dividing the frenum of the tongue; right, breasts with breast cancer and a rectilinear cicatrix after the cure. Engraving with etching by R. Parr.

Be a Shanti volunteer : you can give practical and emotional in-home support to someone living with HIV/AIDS or breast cancer ... / Shanti.

Helianthus annuus Greene Asteraceae. Sunflower, Marigold of Peru, Floure of the Sun. Distribution: Peru and Mexico. It was much recommended by Gerard (1633) who advises that the buds, covered in flour, boiled, and eaten with 'butter, vinegar and pepper, far surpass artichokes in procuring bodily lust’. Sadly, today only the seeds of sunflower are consumed, as the source of sunflower seed oil used in cooking. It contains mono and polyunsaturated fats, linoleic acid and oleic acid, and is low in saturated fats. As such it was thought to lower cholesterol and so the risk of heart disease, but it may increase the risk of breast and prostatic cancer. However a recent report BMJ2013

Recurrent cancerous ulcer of the breast

Taxus baccata L. Taxaceae European Yew. Trees are feminine in Latin, so while Taxus has a masculine ending (-us), its specific name, baccata (meaning 'having fleshy berries' (Stearn, 1994)), agrees with it in gender by having a female ending ( -a). Distribution: Europe. Although regarded as poisonous since Theophrastus, Gerard and his school friends used to eat the red berries (they are technically called 'arils') without harm. Johnson clearly ate the fleshy arils and spat out the seed, which is as poisonous as the leaves. It is a source of taxol, an important chemotherapeutic agent for breast and other cancers. It was first extracted from the bark of T. brevifolia, the Pacific yew tree, in 1966. About 1,100 kg of bark produces 10 g of taxol, and 360,000 trees a year would have been required for the needs of the USA – an unsustainable amount. In 1990 a precursor of taxol was extracted from the needles of the European yew so saving the Pacific trees. It is now produced in fermentation tanks from cell cultures of Taxus. Curiously, there is a fungus, Nodulisporium sylviforme, which lives on the yew tree, that also produces taxol. Because taxol stops cell division, it is also used in the stents that are inserted to keep coronary arteries open. Here it inhibits – in a different way, but like anti-fouling paint on the bottom of ships – the overgrowth of endothelial cells that would otherwise eventually block the tube. The economic costs of anticancer drugs are significant. Paclitaxel ‘Taxol’ for breast cancer costs (2012) £246 every 3 weeks

Forceps invented by Helvetius for the examination and amputation of cancerous breasts. Engraving with etching by R. Parr.

Illustration shows the excision of a cancerous growth from a woman's breast, an operation which Hanaoka Seishu first carried out in 1804 using general anasthetic

Illustration shows the excision of a cancerous growth or tumour from a woman's breast, an operation which Hanaoka Seishu first carried out in 1804 using general anasthetic

Atropa belladonna L. Solanaceae. Deadly nightshade. Dwale. Morella, Solatrum, Hound's berries, Uva lupina, Cucubalus, Solanum lethale. Atropa derives from Atropos the oldest of the three Fates of Greek mythology who cut the thread of Life (her sisters Clotho and Lachesis spun and measured the thread, respectively). belladonna, literally, means 'beautiful lady' and was the Italian name for it. Folklore has it that Italian ladies put drops from the plant or the fruits in their eyes to make themselves doe-eyed, myopic and beautiful. However, this is not supported by the 16th and 17th century literature, where no mention is ever made of dilated pupils (or any of the effects of parasympathetic blockade). Tournefort (1719) says 'The Italians named this plant Belladonna, which in their language signifies a beautiful woman, because the ladies use it much in the composition of their Fucus [rouge or deceit or cosmetic] or face paint.' Parkinson says that the Italian ladies use the distilled juice as a fucus '... peradventure [perhaps] to take away their high colour and make them looke paler.' I think it more likely that they absorbed atropine through their skin and were slightly 'stoned' and disinhibited, which made them beautiful ladies in the eyes of Italian males. Distribution: Europe, North Africa, western Asia. Culpeper (1650) writes: 'Solanum. Nightshade: very cold and dry, binding … dangerous given inwardly … outwardly it helps the shingles, St Antonie's Fire [erysipelas] and other hot inflammation.' Most of the 16th, 17th and 18th century herbals recommend it topically for breast cancers. Poisonous plants were regarded as 'cold' plants as an excess of them caused death and the body became cold. They were regarded as opposing the hot humour which kept us warm and alive. Poultices of Belladonna leaves are still recommended for muscle strain in cyclists, by herbalists. Gerard (1633) writes that it: 'causeth sleep, troubleth the mind, bringeth madnesse if a few of the berries be inwardly taken, but if more be taken they also kill...'. He was also aware that the alkaloids could be absorbed through the skin for he notes that a poultice of the leaves applied to the forehead, induces sleep, and relieves headache. The whole plant contains the anticholinergic alkaloid atropine, which blocks the peripheral actions of acetylcholine in the parasympathetic nervous system. Atropine is a racemic mixture of d- and l- hyoscyamine. Atropine, dropped into the eyes, blocks the acetylcholine receptors of the pupil so it no longer constricts on exposure to bright light - so enabling an ophthalmologist to examine the retina with an ophthalmoscope. Atropine speeds up the heart rate, reduces salivation and sweating, reduces gut motility, inhibits the vertigo of sea sickness, and is used to block the acetylcholine receptors to prevent the effects of organophosphorous and other nerve gas poisons. It is still has important uses in medicine. Atropine poisoning takes three or for days to wear off, and the hallucinations experienced by its use are described as unpleasant. We have to be content with 'madness', 'frenzie' and 'idle and vain imaginations' in the early herbals to describe the hallucinations of atropine and related alkaloids as the word 'hallucination' in the sense of a perception for which there is no external stimulus, was not used in English until 1646 (Sir T. Browne, 1646). It is a restricted herbal medicine which can only be sold in premises which are registered pharmacies and by or under the supervision of a pharmacist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Mrs Prince, after surgical removal of a breast. Watercolour, 1841.

Taxus Baccata (Yew)

MS Japanese 18

Mastectomy. Drawing attributed to a Dutch artist, 17th century.

Taxus baccata (English yew)

Surgical instruments used, and operations successfully carried out, by an English travelling operator claiming royal patronage. Line engraving, 16--.

Table XLII-XLIII. A medicinal dictionary, 1743-45.

Plate LVI. Surgery for the removal of the mammary gland.

Disease and organs treated by a vodoo practitioner in Benin. Acrylic paintings, 199-.

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