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  • Hypericum olympicum L. Clusiaceae. Mount Olympus St John's wort. Deciduous perennial herb. Distribution Greece, Asia minor. This is not the plant used for mood disturbances in herbal medicine which is Hypericum perforatum. However, all the 370 species of Hypericum are called 'St John's Wort' so a potential for confusion exists. It shares some of the chemicals thought to be active in Hypericum perforatum. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • London School of Tropical Medicine (10th Session) group portrait including Sir Patric Manson, M.C. Blair, R.F. de Boissiere, C.W. Daniels, A.H. Davies, J.T. Hancock O. Galgey, and E. Da Cunha, G. Hungerford, Sir Francis Lovell, J. Lunn, G. Lecesne, W.S. Milne, T. Hood, M. Sandeman, D. Steel, Dr. Sambon, G.D. Warren, Charles and Robert the lab assistants
  • Rosa gallica L. Rosaceae Distribution: S & C Europe, Western Asia. Culpeper: “Red roses cool, bind, strengthen both vital and animal virtue, restores such as are in consumptions, strengthen. Notes: Rose water and distilled oil of roses have been used in herbal medicine for over a thousand years, and are still used in aromatherapy. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Rudbeckia triloba L. Asteraceae Orange Cone flower. Herbaceous perennial. Distribution: North America. It is named for Olof Rudbeck, father (1630–1702) and son (1660–1740). Olof Rudbeck the Elder was professor of medicine at Uppsala University, and established a botanic garden there. He was the discoverer of the human lymphatic system. His son succeeded his father as professor of medicine, and one of his students was Carl Linnaeus (1707–88) who named the genus Rudbeckia after him and his father. It is a plant which is poisonous to cattle, sheep and pigs with no medicinal uses. Austin (1974) discusses R. hirta, also regarded as a toxic plant. It was used externally by the Cherokee to bathe sores and snakebites and made into a tea for treating diarrhoea. The Seminoles used it for headaches and fever and the Miccosukee for sunstroke and headache. The Cherokee and the Iroquois used it to treat intestinal worms Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Eucomis comosa (Houtt.)H.R.Wehrh. Hyacinthaceae Pineapple flower. From the Greek eu comis meaning 'good hair' referring to the tuft of leaves on top of the flowers. Comosa being Latin for 'with a tuft' referring to the same thing. Used in South African 'muthi' medicine. Enemas of Eucomis autumnalis are used in Africa to treat low backache, to aid postoperative recovery and to speed the healing of fractures. Decoctions are taken for the treatment of everything from hangovers to syphilis. The active ingredients include homisoflavones, which have anti-inflammatory and antispasmodic activity (van Wyk et al, 2000) Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Eucomis comosa (Houtt.)H.R.Wehrh. Hyacinthaceae Pineapple flower. From the Greek eu comis meaning 'good hair' referring to the tuft of leaves on top of the flowers. Comosa being Latin for 'with a tuft' referring to the same thing. Used in South African 'muthi' medicine. Enemas of Eucomis autumnalis are used in Africa to treat low backache, to aid postoperative recovery and to speed the healing of fractures. Decoctions are taken for the treatment of everything from hangovers to syphilis. The active ingredients include homisoflavones, which have anti-inflammatory and antispasmodic activity (van Wyk et al, 2000). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Dianthus caryophyllus L. Caryophyllaceae Carnation, clove-gilliflowers - Mediterranean Culpeper (1650) writes that ‘Clove-gilliflowers, resist the pestilence, strengthen the heart, liver and stomach, and provokes lust.’ They smell strongly of cloves, and an oil made from the petals is used in perfumery, soaps etc. The petals are sometimes used as a garnish for salads. In herbal medicine they are used to make a tonic. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Aconitum carmichaelii Debeaux. Ranunculaceae. Chinese aconite, Chinese wolfsbane, Carmichael's monkshood. Herbaceous perennial. Distribution C. to W. China to N. America. Named for Dr J.R. Carmichael (d. 1877), English physician, plant collector and Protestant missionary from 1862-1877 in Guangdong and Shandong, China initially in Canton. He aided Francis Forbes to collect plants for Kew. Aconitum plants are so poisonous that Theophrastus states that death was the punishment for possessing them. Aconitine is the poison and was used - from Aconitum ferox - in the 'curry murder' in London in 2009. It causes respiratory paralysis, bradycardia (slowing of the pulse), cardiac arrhythmias, tingling, sweating, gastric cramps, diarrhoea and death, both by ingestion and by absorption through the mucous membranes and the skin. Despite this it is widely used in Chinese herbal medicine. It is a restricted herbal medicine which can only be dispensed by a herbal practitioner for external use following a one-to-one consultation, or by prescription from a registered doctor or dentist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • The face of a woman in speckled black ink with her eyes scratched in green representing an advertisement for an international exhibition of AIDS posters entitled 'Visual AIDS' from 6 to 19 November 1989 by the Berliner AIDS-Hilfe e.V and Deutschen AIDS-Hilfe e.V; a project of the seminar "AIDS and the Arts" of the University of Western Ontario in collaboration with the AIDS-Hilfe London and Canada. Colour lithograph by Detlev Pusch.
  • Scutellaria baicalensis Georgi Lamiaceae. Baikal skullcap. Distribution: China. There are several hundred species of Scutellaria, also known as skull caps, so correct identification is important - in particular from Scutellaria lateriflora an American species known as Blue skullcap. The latter is used as an abortifacient and to expel placenta by the Cherokee and for cleaning the throat by the Iroquois (Austin, 2004). Much vaunted as a treatment for rabies with unlikely statistics (1,400 cases cured by one doctor alone). Also as ‘antispasmodic, nervine, [for] chorea, convulsions, tetanus, tremors, delirium tremens, [and as a] diaphoretic and diuretic'. Toxicity symptoms include mental confusion, stupor, headache, vertigo, photophobia, dilated pupils, difficulty in micturition, bradycardia, tremulousness and languor, followed by wakefulness and restlessness (Milspaugh, 1974). Hutchens (1991) reported that it reduces sexual desire and was used for almost every nervous illness. Scutellaria baicalensis contains baicalin, baicalein and wogonin (European Medicines Agency, September 2010). It is used in Traditional Chinese Medicine for treating inflammation, cancer, bacterial and viral infections of the lungs and gut and is one of the '50 Chinese herbs' in the lists of some authors. Scutellaria lateriflora (combined with Verbena officinalis, Passiflora incarnata and the seed of Avena sativa (oats) is licensed for use in Britain as a herbal medicine for temporary relief of mild symptoms of stress such as mild anxiety and to aid sleep, based upon traditional use only. Scutellaria baicalensis is not licensed for use in the UK (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • We, the court of examiners, chosen and appointed by the master, wardens and assistants of the Society of the Art and Mystery of Apothecaries of the City of London in pursuance of a certain Act of Parliament passed in the 55th year of the reign of his majesty King George the third entitled an Act for the better regulating the practice of apothecaries throughout England and Wales, do hereby by virtue of the power & authority invested by the said Act certify that ... has been by us carefully and deliberately examined as to his skills & abilities in the science & practice of medicine ... duly qualified as an apothecary.
  • Cucurbita pepo L., Cucurbitaceae. Distribution: Mexico (extinct) This species is one of the oldest cultivated plants, first grown 11,000 years ago in Mexico, but extinct in the wild. Varieties are selectively bred for their taste, colour and shape. The seeds, ground to a powder are used to kill intestinal tape-worms (Lewis & Elvin-Lewis, 2003). This is a 200-year-old cultivar whose seed has been conserved by the Amish of Pennsylvania, USA. The rind is very thick, but the taste is delicious. This is a 200-year-old cultivar whose seed has been conserved by the Amish of Pennsylvania, USA. The rind is very thick, but the taste is delicious. Seeds approved for use in making herbal medicines in the UK (Herbal Medicine legislation 2013) Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Scabiosa columbaria L. Dipsacaceae. Small scabious. Distribution: Europe. Culpeper (1650) writes: ‘The roots either boiled or beaten into powder and so taken, helps such as are extremely troubled with scabs and itch, are medicinal in the French-pocks [syphilis], hard swellings, inward wounds ...’ The genus name comes from the Latin word scabies, meaning ‘itch’. According to the Doctrine of Signatures, the rough leaves indicated that it would cure eczematous skin. However, the leaves are not really very rough... Not used in herbal medicine at the present time except in Southern Africa where it is used for colic and heartburn, and the roots made into an ointment for curing wounds (van Wyk, 2000). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Gardenia jasminoides J.Ellis Rubiaceae. Cape jasmine - as erroneously believed to have come from South Africa. Distribution: China. Named for Dr Alexander Garden FRS (1730-1791) Scottish-born physician and naturalist who lived in Charles Town, South Carolina, and corresponded with Linnaeus and many of the botanists of his era. The fruits are used in China both as a source of a yellow dye, and for various unsubstantiated medicinal uses. Other species of Gardenia are found in tropical Africa and the roots and leaves have all manner of putative uses. Gardenia tenuifolia is used as an aphrodisiac, for rickets, diarrhoea, leprosy, gall bladder problems, toothache, liver complaints, diabetes, hypertension, malaria and abdominal complaints. It causes violent vomiting and diarrhoea. It, and other species, are used to poison arrows and to poison fish. Some native, muthi medicine, healers regard Gardenia as a ‘last chance’ medicine, given to patients when all else fails – the patient either dies or recovers (Neuwinger, 1996). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Viola canina L. Violaceae Distribution: Europe. Culpeper (1650) writes 'Violets (to whit the blew ones, for I know little or no use of the white ones in physic) ... provoke sleep, loosen the belly, resist fevers, help inflammations, ... ease pains in the head, help the roughness of the windpipe, soreness in the throat, inflammations in the breast and sides, pleurisies, open stoppings of the liver and help the yellow jaundice'. 'Violet leaves, they are cool, ease pains in the head proceeding of heat, and frenzies, either inwardly taken or outwardly applied, heat of the stomach, or inflammation of the lungs.' It still has the same reputation in modern herbal medicine, and while its safety is not known, it is regarded as edible and flowers are used to garnish salads. Larger quantities are emetic – make one vomit. Not licensed for use in Traditional Herbal Medicines in the UK (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Salvia coahuilensis Fernald Lamiaceae Coahuila Sage. Perennial shrub. Distribution: Mexico. Most of the historical medicinal literature is on common sage, Salvia officinalis. The name Salvia meaning 'healthy'. Elizabeth Blackwell (1737) wrote that it had "... all the noble Properties of the other hot Plants more especially for the Head, Memory, Eyes, and all Paralytical Affections. In short, 'tis a Plant endu'd with so many and wonderful Properties, as that the assiduous use of it is said to render Men Immortal" with which Hans Sloane agreed. Its health giving properties were recorded in the aphorisms of the School of Salerno (fl 9-13th century) - quoted in the Decameron [c.1350, translated: Why should man die when Salvia grows in the Garden']. Some salvias, such as Salvia divinorum contain hallucinogenic compounds. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Polygonum bistorta L. Polygonaceae Bistort, snakeweed, Easter Ledges. Distribution: Europe, N & W Asia. Culpeper: “... taken inwardly resist pestilence and poison, helps ruptures, and bruises, stays fluxes, vomiting and immoderate flowing of the terms in women, helps inflammations and soreness of the mouth, and fastens loose teeth, being bruised and boiled in white wine and the mouth washed with it.” In modern herbal medicine it is still used for a similar wide variety of internal conditions, but it can also be cooked and eaten as a vegetable. The use to relieve toothache, applied as a paste to the affected tooth, seems to have been widespread. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Salvia nemorosa L. Lamiaceae Woodland sage. Balkan clary Distribution: Central Europe, Western Asia. Most of the historical medicinal literature is on common sage, Salvia officinalis. The name Salvia meaning 'healthy'. Elizabeth Blackwell (1737) wrote that it had "... all the noble Properties of the other hot Plants more especially for the Head, Memory, Eyes, and all Paralytical Affections. In short, 'tis a Plant endu'd with so many and wonderful Properties, as that the assiduous use of it is said to render Men Immortal" with which Hans Sloane agreed. Linnaeus (1782) also: 'Timor, Languor, Leucorrhoea, Senectus [fear, tiredness, white vaginal discharge, old age]'. Its health giving and immortality conferring properties were recorded in the aphorisms of the School of Salerno (fl 9-13th century) - quoted in the Decameron [c.1350, translated: Why should man die when Salvia grows in the Garden']. Some salvias, such as Salvia divinorum contain hallucinogenic compounds. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Zantedeschia aethiopica (L)Spreng. Calla lily, Arum lily. Half hardy annual. Distribution: South Africa. The genus name commemorates Giovanni Zantedeschi (1773-1846) an Italian physician and botanist. Born in Molina he studied medicine in Verona and Padua. He corresponded with the German botanist, Kurt Sprengel, who named the genus Zantedeschia in his honour in 1826, separating it from Calla, where, as C. aethiopica, it had been previously described by Linnaeus. He had broad interests, including the effect of different parts of the spectrum of light on plant growth, reporting in 1843, that red, orange and yellow light are heliotropically inactive. The botanic museum in Molina is dedicated to his memory. Aethiopica, merely means 'African'. The leaves are used as a warm poultice for headaches in ‘muthi’ medicine. It has become an invasive weed in parts of Australia. It was introduced, as a greenhouse plant, to Europe in the mid-17th century, where the long lasting flowers are popular in flower arranging and for weddings and funerals – a curious combination (Oakeley, 2012). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Hacquetia epipactis DC Apiaceae. Small herbaceous perennial. No common name except Hacquetia Distribution: Europe. Named for the Austrian physician, Balthasar (or Belsazar) Hacquet (1739/40-1815). He studied medicine in Vienna, was a surgeon in the brutal Seven Years War (1756-1763) – a world-wide war in which up to 1,400,000 people died. Later he was professor at the University of Lemberg (1788-1810). He wrote widely on many scientific disciplines including geology. Parkinson (1640) grouped it with Helleborus and Veratrum, calling it 'Epipactis Matthioli, Matthiolus, his bastard black hellebore' but does not give any uses. It has no medicinal properties. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Agrimonia eupatoria L. Agrimony, Eupatorium, Maudlein. Perennial herb. The species name comes from king Mithridates Eupator VI of Pontus (132-63 BC) who took regular doses of poison to develop an immunity to them. A 'Mithridate' was a medicine against poisons. Distribution: N. and S. Africa, N. Asia, Europe. '…provokes urine and the terms [periods], dries the brain, opens stoppings, helps the green sickness [iron deficiency anaemia], and profits such as have a cold weak liver outwardly applied it takes away the hardness of the matrix [=uterus] and fills hollow ulcers with flesh' (Culpeper, 1650). Dioscorides (Beck, 2005) recommends mashed leaves in hog's grease for healing scarring ulcers, and the seed in wine for dysentery and serpent bites. Goodyear's 1655 translation of Dioscorides (Gunther 2000) has this as cannabis, which Parkinson (1640) says is in error and summarises the manifold uses from classical authors, from removing splinters to stopping menorrhagia. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Licensed as a Traditional Herbal Remedy in the UK (Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Arctium lappa L. Asteraceae. Greater Burdock. Distribution: Europe to India and Japan. Dioscorides (Beck, 2003) writes: '... helps those who spit blood and who suffer from abscesses ... plastered on it stems the pains around the joints that stem from twistings. The Leaves are applied beneficially on old ulcers.' Culpeper (1650) writes: ‘Burdanae, etc. Of Bur, Clot-Bur or Burdock, ... helps such as spit blood and matter, bruised and mixed salt and applied to the place, helpeth the bitings of mad dogs. It expels wind, easeth pains of the teeth, strengthens the back, helps the running of the reins, and the whites in women, being taken inwardly.’ The roots contain inulin, which is made into a non-digestible sweetener for diabetics. It has a multitude of uses in herbal medicine, in particular it is a component of a compound called ‘essiac’ that has been widely used as a treatment of cancers in the USA, but which is of no proven benefit. The young roots can be eaten raw or cooked. The seeds are hairy and care should be taken when harvesting them as inhaled they are reported as ‘toxic’. The root is licensed for use in Traditional Herbal Medicines in the UK (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. Combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • A man dressed in white with a blue turban holding a white sack greets a woman in a blue sari and her child on a rural road next to her hut; his horse and cart with further white sacks wait idle nearby; with a message about the dangers of having unprotected sex with foreign women; an AIDS prevention advertisement by NGO-AIDS Cell, Centre for Community Medicine, AIIMS. Colour lithograph by Unesco/Aidthi Workshop, March 1995.
  • Valeriana officinalis L. Valerianaceae Valerianus, Phu, Nardus sylvestris, Setwal. Distribution: Europe. Popular herbalism attributes sedation to Valerian, but this is not mentioned by Coles (1657) or Gerard (1633) or Lobel (1576) or Lyte (1578) or Dioscorides (ex Gunther, 1959) or Fuchs (1553), where he quotes Pliny, Dioscorides and Galen, or Parkinson (1640), or Pomet (1712). The English translation of Tournefort (1719-1730) covers a whole page of the uses of all the different valerians, but never mentions sedation or treating anxiety. Quincy (1718) does not mention it. Because it was used in epilepsy, for which Woodville (1792) says it was useless, Haller, in his Historia stirpium indegenarum Helvetae inchoatae (1768) advocates it for those with irritability of the nervous system, as does Thomson's London Dispensatory (1811) although he lists it as an 'antispasmodic and stimulant' and for inducing menstruation. Lindley (1838) notes (as many did) that the roots smell terrible and that this makes cats excited, and in man, in large doses, induce 'scintillations, agitation and even convulsions' so used in asthenic fever, epilepsy, chorea, hysteria and as an antihelminthic.' Fluckiger & Hanbury (1879) give a wonderful account of the history of its names, but give its use as 'stimulant and antispasmodic' as do Barton & Castle (1877). but by 1936 (Martindale's Extra Pharmacopoeia) its only use was 'Given in hysterical and neurotic conditions as a sedative. Its action has been attributed to its unpleasant smell'. The European Medicines Agency (2006) approves its use as a traditional herbal medicine for mild anxiety and sleeplessness for up to 4 weeks. Despite what is written continuously about its use in ancient Greece and Rome, the only reason for its use has been because it was thought, for a brief while, to be good for epilepsy and therefore might deal with persons of a nervous disposition because of its foul smell. It has been suggested that even its Greek name, 'Phu' came from the expression of disgust which is made when one sniffs an unpleasant odour. For 1,800 years, before the last century, no-one had thought it sedative. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Fuchsia magellanica Lam. Onagraceae. Hardy fuchsia. Semi-hardy shrub. Distribution: Mountainous regions of Chile and Argentina where they are called 'Chilco' by the indigenous people, the Mapuche. The genus was discovered by Charles Plumier in Hispaniola in 1696/7, and named by him for Leonhart Fuchs (1501-1566), German Professor of Medicine, whose illustrated herbal, De Historia Stirpium (1542) attempted the identification of the plants in the Classical herbals. It also contained the first accounts of maize, Zea mays, and chilli peppers, Capsicum annuum, then recently introduced from Latin America. He was also the first person to publish an account and woodcuts of foxgloves, Digitalis purpurea and D. lutea. The book contains 500 descriptions and woodcuts of medicinal plants, arranged in alphabetical order, and relied heavily on the De Materia Medica (c. AD 70) of Dioscorides. He was a powerful influence on the herbals of Dodoens, and thence to Gerard, L’Escluse and Henry Lyte. A small quarto edition appeared in 1551, and a two volume facsimile of the 1542 edition with commentary and selected translations from the Latin was published by Stanford Press in 1999. The original woodcuts were passed from printer to printer and continued in use for 232 years (Schinz, 1774). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.