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  • Betony (Stachys officinalis (L.) Trev.): flowering stem with separate leaves, floral segments and sections of root and a description of the plant and its uses. Coloured line engraving after T. Sheldrake, c.1759.
  • Gardenia jasminoides J.Ellis Rubiaceae. Cape jasmine - as erroneously believed to have come from South Africa. Distribution: China. Named for Dr Alexander Garden FRS (1730-1791) Scottish-born physician and naturalist who lived in Charles Town, South Carolina, and corresponded with Linnaeus and many of the botanists of his era. The fruits are used in China both as a source of a yellow dye, and for various unsubstantiated medicinal uses. Other species of Gardenia are found in tropical Africa and the roots and leaves have all manner of putative uses. Gardenia tenuifolia is used as an aphrodisiac, for rickets, diarrhoea, leprosy, gall bladder problems, toothache, liver complaints, diabetes, hypertension, malaria and abdominal complaints. It causes violent vomiting and diarrhoea. It, and other species, are used to poison arrows and to poison fish. Some native, muthi medicine, healers regard Gardenia as a ‘last chance’ medicine, given to patients when all else fails – the patient either dies or recovers (Neuwinger, 1996). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Lathyrus vernus (L.)Bernh. Papilionaceae previously Orobus vernus L. (Linnaeus, 1753) Spring vetchling. Distribution: Europe to Siberia. The seeds of several Lathyrus species are toxic, and when eaten cause a condition called lathyrism. The chemical diaminoproprionic acid in the seeds causes paralysis, spinal cord damage, aortic aneurysm, due to poisoning of mitochondria causing cell death. Occurs where food crops are contaminated by Lathyrus plants or where it is eaten as a 'famine food' when no other food is available. It is the Orobus sylvaticus purpureus vernus of Bauhin (1671) and Orobus sylvaticus angustifolius of Parkinson (1640) - who records that country folk had no uses for it. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Lathyrus vernus (L.)Bernh. Papilionaceae previously Orobus vernus L. (Linnaeus, 1753) Spring vetchling. Distribution: Europe to Siberia. The seeds of several Lathyrus species are toxic, and when eaten cause a condition called lathyrism. The chemical diaminoproprionic acid in the seeds causes paralysis, spinal cord damage, aortic aneurysm, due to poisoning of mitochondria causing cell death. Occurs where food crops are contaminated by Lathyrus plants or where it is eaten as a 'famine food' when no other food is available. It is the Orobus sylvaticus purpureus vernus of Bauhin (1671) and Orobus sylvaticus angustifolius of Parkinson (1640) - who records that country folk had no uses for it. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Carthamus tinctorius L. Asteraceae. Safe Flower, False Saffron - Distribution: W. Asia. Dioscorides (in Beck, 2003) notes the seeds as a purgative, but also advises it made up with 30 figs, which must have helped. Gerard (1640) calls it Atractylis flore luteo the yellow distaffe thistle. and follows Dioscorides in its uses, but does get the reader confused with Cnicus benedictus, calling both plants 'wild bastard saffron'. Culpeper makes no mention of it in his early works, but later (1826) have the following: ‘Wild Saffon, or Saf-flower ... accounted a pretty strong cathartic [causing diarrhoea and vomiting], evacuating tough viscid phlegm, both upwards and downwards, and by that means is said to clear the lungs, and help the phthisic [now equated with tuberculosis]. It is likewise serviceable against the jaundice
  • Translocation - use of cosmid probe
  • Senna corymbosa (Lam.)H.S.Irwin&Barneby Caesalpinaceae. Argentine Senna. Distribution: Argentine (other species from Europe). This beautiful shrub that flowers from midsummer until the frosts of winter, is the source of one of the best known of all herbal medicines – Senokot (and senna pods and senna tea), introduced to European medicine (as Senna alexandrina from Egypt) by the Arabians. Every part of the plant contains anthraquinones which, if taken internally, act as a powerful laxative to treat constipation by stimulating the nerve cells of the large bowel. Gerard (1633) notes ‘it is a singular purging medicine’ with over a page on its uses. When used regularly the nerves to the large bowel may be destroyed, leaving a permanently dilated large bowel that never functions properly again. This is a plant which causes the condition it treats to become permanent. Additionally, with prolonged use, the lining of the bowel turns black, serum potassium levels may fall, resulting in cardiac irregularities and sometimes death. Coma, neuropathy and hepatitis have also been reported. It is advertised on television (the actor involved is seen to be depressed and bloated until she takes Senokot, after which she is happy - Hippocrates would have attributed this antidepressant effect to the plant's ability to purge her of the black melancholic humour present in her bowel motions). It is available without prescription or health warning against long-term use. What do you think? Lyte (1578) recommends it strongly for depression, but one might claim to be cured rather than take it again. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Senna corymbosa (Lam.)H.S.Irwin&Barneby Caesalpinaceae. Argentine Senna. Distribution: Argentine (other species from Europe). This beautiful shrub that flowers from midsummer until the frosts of winter, is the source of one of the best known of all herbal medicines – Senokot (and senna pods and senna tea), introduced to European medicine (as Senna alexandrina from Egypt) by the Arabians. Every part of the plant contains anthraquinones which, if taken internally, act as a powerful laxative to treat constipation by stimulating the nerve cells of the large bowel. Gerard (1633) notes ‘it is a singular purging medicine’ with over a page on its uses. When used regularly the nerves to the large bowel may be destroyed, leaving a permanently dilated large bowel that never functions properly again. This is a plant which causes the condition it treats to become permanent. Additionally, with prolonged use, the lining of the bowel turns black, serum potassium levels may fall, resulting in cardiac irregularities and sometimes death. Coma, neuropathy and hepatitis have also been reported. It is advertised on television (the actor involved is seen to be depressed and bloated until she takes Senokot, after which she is happy - Hippocrates would have attributed this antidepressant effect to the plant's ability to purge her of the black melancholic humour present in her bowel motions). It is available without prescription or health warning against long-term use. What do you think? Lyte (1578) recommends it strongly for depression, but one might claim to be cured rather than take it again. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Pulmonaria officinalis L. Boraginaceae Distribution: Officinalis indicates its medicinal use in early medicine. Europe. Pulmonaria or Lungwort are names for a lichen and a perennial plant in the Boraginaceae. This is the latter. Lyte (1578) has a woodcut of our plant and also calls it Sage of Jerusalem and says it is of ' no particular use in physicke, but is much used in meates and salads with eggs, as is also Cowslippes and Primroses, whereunto in temperature it is much alike.' He lists and describes the lichen separately. Culpeper (1650) said he found many sorts of lunguewort in perusing Authors ' Pulmonari, arborea and Symphytum maculosum [and the latter is our plant, the others the lichen] and that they 'helpe infirmities of the lungues, as hoarseness, coughs, wheezing, shortnesse of breath etc.' Coles (1657) who espouses the Doctrine of Signatures in a way unrivalled by any other English author, might have been expected to confirm the concept that the mottled leaves looked like the cut surface of a lung which indicates their purpose, but he only mentions the lungwort which is a lichen. However, Porta's beautiful book on the Doctrine, Phytognomica (1588), is clear that the plant called Pulmonaria with hairy leaves like a bugloss, spotted white with purple flowers, commonly called 'cynoglossa' [with a woodcut which could be Pulmonaria officinalis] indicate its use for ulcerated lungs, spitting blood, shortness of breath and asthma equally with the lichen with the same name. Lobel & Pena (1570) call it 'PULMONARIA, masculosa folia Borrago, floribus Primula veris, purpureis [PULMONARIA spotted, Borage-leaved, flowers like Primula veris - Cowslips - purple]' and say that women mix the leaves with a little broth and make it into an omelette for lung disorders and to strengthen the heart. Lobel (1576) calls it Maculosa Pulmonaria and describes a white flowered form with a good woodcut. Gerard (1633) uses the same woodcut as Lobel and calls it Pulmonatia foliis Echii, Buglosse Cowslips with red flowers, and a woodcut of a narrow leaved plant as Pulmonaria masculosa, Spotted Cowslips of Jerusalem with red, blue and purple flowers and says 'the leaves are used among pot-herbes. The roots are aso thought to be good against the infirmities of ulcers of the lungs...'. Quincy (1718) writes: '... it has a glutinous juice ... and heals ulcers and erosions. It is commended in coughs and spitting of blood but is little used either in the Shop or Prescriptions. Not used in modern medicine. It is in the family Boraginaceae whose species are often rich in pyrrolizidine alkaloids that cause liver toxicity and liver cancers, but levels in Pulmonaria officinalis may not be significant. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Pulmonaria officinalis L. Boraginaceae Distribution: Europe. Pulmonaria or Lungwort are names for a lichen and a perennial plant in the Boraginaceae. This is the latter. Lyte (1578) has a woodcut of our plant and also calls it Sage of Jerusalem and says it is of 'no particular use in physicke, but is much used in meates and salads with eggs, as is also Cowslippes and Primroses, whereunto in temperature it is much alike.' He lists and describes the lichen separately. Culpeper (1650) said he found many sorts of lunguewort in perusing Authors ' Pulmonari, arborea and Symphytum maculosum [and the latter is our plant, the others the lichen] and that they 'helpe infirmities of the lungues, as hoarseness, coughs, wheezing, shortnesse of breath etc.' Coles (1657) who espouses the Doctrine of Signatures in a way unrivalled by any other English author, might have been expected to confirm the concept that the mottled leaves looked like the cut surface of a lung which indicates their purpose, but he only mentions the lungwort which is a lichen. However, Porta's beautiful book on the Doctrine, Phytognomica (1588), is clear that the plant called Pulmonaria with hairy leaves like a bugloss, spotted white with purple flowers, commonly called 'cynoglossa' [with a woodcut which could be Pulmonaria officinalis] indicate its use for ulcerated lungs, spitting blood, shortness of breath and asthma equally with the lichen with the same name. Lobel & Pena (1570) call it 'PULMONARIA, masculosa folia Borrago. floribus Primula veris, purpureis [PULMONARIA spotted, Borage-leaved, flowers like Primula veris - Cowslips - purple]' and say that women mix the leaves with a little broth and make it into an omelette for lung disorders and to strengthen the heart.. Lobel (1576) calls it Maculosa Pulmonaria and describes a white flowered form with a good woodcut. Gerard (1633) uses the same woodcut as Lobel and calls it Pulmonatia foliis Echii, Buglosse Cowslips with red flowers, and a woodcut of a narrow leaved plant as Pulmonaria masculosa, Spotted Cowslips of Jerusalem with red, blue and purple flowers and says 'the leaves are used among pot-herbes. The roots are aso thought to be good against the infirmities of ulcers of the lungs...'. Quincy (1718) writes: '... it has a glutinous juice ... and heals ulcers and erosions. It is commended in coughs and spitting of blood but is little used either in the Shop or Prescriptions'. Not used in modern medicine. It is in the family Boraginaceae whose species are often rich in pyrrolizidine alkaloids that cause liver toxicity and liver cancers, but levels in Pulmonaria officinalis may not be significant. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Pulmonaria rubra L. Boraginaceae A red-flowered species, mentioned in 16th and 17th herbals, but with the same properties as officinalis. Distribution: Europe. Pulmonaria or Lungwort are names for a lichen and a perennial plant in the Boraginaceae. This is the latter. Lyte (1578) has a woodcut of our plant and also calls it Sage of Jerusalem and says it is of 'no particular use in physicke, but is much used in meates and salads with eggs, as is also Cowslippes and Primroses, whereunto in temperature it is much alike.' He lists and describes the lichen separately. Culpeper (1650) said he found many sorts of lunguewort in perusing Authors 'Pulmonari, arborea and Symphytum maculosum [and the latter is our plant, the others the lichen] and that they 'helpe infirmities of the lungues, as hoarseness, coughs, wheezing, shortnesse of breath etc.' Coles (1657) who espouses the Doctrine of Signatures in a way unrivalled by any other English author, might have been expected to confirm the concept that the mottled leaves looked like the cut surface of a lung which indicates their purpose, but he only mentions the lungwort which is a lichen. However, Porta's beautiful book on the Doctrine, Phytognomica (1588), is clear that the plant called pulmonaria with hairy leaves like a bugloss, spotted white with purple flowers, commonly called 'cynoglossa' [with a woodcut which could be Pulmonaria officinalis] indicate its use for ulcerated lungs, spitting blood, shortness of breath and asthma equally with the lichen with the same name. Lobel & Pena (1570) call it 'PULMONARIA, masculosa folia Borrago. floribus Primula veris, purpureis[ PULMONARIA spotted, Borage-leaved, flowers like Primula veris - Cowslips - purple] and say that women mix the leaves with a little broth and make it into an omelette for lung disorders and to strengthen the heart. Lobel (1576) calls it Maculosa Pulmonaria and describes a white flowered form, with a good woodcut. Gerard (1633) uses the same woodcut as Lobel and calls it Pulmonatia foliis Echii, Buglosse Cowslips with red flowers, and a woodcut of a narrow leaved plant as Pulmonaria masculosa, Spotted Cowslips of Jerusalem with red, blue and purple flowers and says 'the leaves are used among pot-herbes. The roots are aso thought to be good against the infirmities of ulcers of the lungs...'. Quincy (1718) writes: '... it has a glutinous juice ... and heals ulcers and erosions. It is commended in coughs and spitting of blood but is little used either in the Shop or Prescriptions. Not used in modern medicine. It is in the family Boraginaceae whose species are often rich in pyrrolizidine alkaloids that cause liver toxicity and liver cancers, but levels in Pulmonaria officinalis may not be significant. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Atropa belladonna L. Solanaceae. Deadly nightshade. Dwale. Morella, Solatrum, Hound's berries, Uva lupina, Cucubalus, Solanum lethale. Atropa derives from Atropos the oldest of the three Fates of Greek mythology who cut the thread of Life (her sisters Clotho and Lachesis spun and measured the thread, respectively). belladonna, literally, means 'beautiful lady' and was the Italian name for it. Folklore has it that Italian ladies put drops from the plant or the fruits in their eyes to make themselves doe-eyed, myopic and beautiful. However, this is not supported by the 16th and 17th century literature, where no mention is ever made of dilated pupils (or any of the effects of parasympathetic blockade). Tournefort (1719) says 'The Italians named this plant Belladonna, which in their language signifies a beautiful woman, because the ladies use it much in the composition of their Fucus [rouge or deceit or cosmetic] or face paint.' Parkinson says that the Italian ladies use the distilled juice as a fucus '... peradventure [perhaps] to take away their high colour and make them looke paler.' I think it more likely that they absorbed atropine through their skin and were slightly 'stoned' and disinhibited, which made them beautiful ladies in the eyes of Italian males. Distribution: Europe, North Africa, western Asia. Culpeper (1650) writes: 'Solanum. Nightshade: very cold and dry, binding … dangerous given inwardly … outwardly it helps the shingles, St Antonie's Fire [erysipelas] and other hot inflammation.' Most of the 16th, 17th and 18th century herbals recommend it topically for breast cancers. Poisonous plants were regarded as 'cold' plants as an excess of them caused death and the body became cold. They were regarded as opposing the hot humour which kept us warm and alive. Poultices of Belladonna leaves are still recommended for muscle strain in cyclists, by herbalists. Gerard (1633) writes that it: 'causeth sleep, troubleth the mind, bringeth madnesse if a few of the berries be inwardly taken, but if more be taken they also kill...'. He was also aware that the alkaloids could be absorbed through the skin for he notes that a poultice of the leaves applied to the forehead, induces sleep, and relieves headache. The whole plant contains the anticholinergic alkaloid atropine, which blocks the peripheral actions of acetylcholine in the parasympathetic nervous system. Atropine is a racemic mixture of d- and l- hyoscyamine. Atropine, dropped into the eyes, blocks the acetylcholine receptors of the pupil so it no longer constricts on exposure to bright light - so enabling an ophthalmologist to examine the retina with an ophthalmoscope. Atropine speeds up the heart rate, reduces salivation and sweating, reduces gut motility, inhibits the vertigo of sea sickness, and is used to block the acetylcholine receptors to prevent the effects of organophosphorous and other nerve gas poisons. It is still has important uses in medicine. Atropine poisoning takes three or for days to wear off, and the hallucinations experienced by its use are described as unpleasant. We have to be content with 'madness', 'frenzie' and 'idle and vain imaginations' in the early herbals to describe the hallucinations of atropine and related alkaloids as the word 'hallucination' in the sense of a perception for which there is no external stimulus, was not used in English until 1646 (Sir T. Browne, 1646). It is a restricted herbal medicine which can only be sold in premises which are registered pharmacies and by or under the supervision of a pharmacist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • A man in a suit smiling with one finger raised, advocating use of condoms for gay men; an advertisement for safe sex by the Authority of Labor, Health and Social Affairs, Hamburg and the Office of Public Health - Health Promotion / AIDS. Colour lithograph by Transglobe Black Box and DMB&B.
  • The side view of two naked men standing to the right with one arm around each other and the message in German: 'use condoms - cool and safe''; an advertisement for safe sex by the AIDS-Hilfe Schweiz, AIDS Suisse Contre le SIDA and Aiuto AIDS Svizzero. Lithograph, 1990.
  • Borago officinalis L. Boraginaceae. Borage. officinalis indicates it was used in the 'offices' - the consulting clinics - of medieval monks. Distribution: Europe. Culpeper: “... comforts the heart, cheers the spirit, drives away sadness and melancholy, they are rather laxative than binding
  • Hacquetia epipactis DC Apiaceae. Small herbaceous perennial. No common name except Hacquetia Distribution: Europe. Named for the Austrian physician, Balthasar (or Belsazar) Hacquet (1739/40-1815). He studied medicine in Vienna, was a surgeon in the brutal Seven Years War (1756-1763) – a world-wide war in which up to 1,400,000 people died. Later he was professor at the University of Lemberg (1788-1810). He wrote widely on many scientific disciplines including geology. Parkinson (1640) grouped it with Helleborus and Veratrum, calling it 'Epipactis Matthioli, Matthiolus, his bastard black hellebore' but does not give any uses. It has no medicinal properties. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Questions about AIDS : call us at National AIDS Helplines : take a free card : phone free - in confidence / prepared by the Department of Health and the Central Office of Information.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. Combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Echinacea purpurea (L.) Moench Asteraceae. Coneflower. Distribution: North America. Austin (2004) records that the roots were chewed, or used as a tincture for coughs by the Choctaw. It was combined with Rhus typhina to treat venereal disease by the Delaware. Very little record of this being used by Native Americans, who used E. angustifolia very widely - Regarded as a panacea and magical herb. This and E. pallida were used to treat snakebite, spider bite, cancer, toothache, burns, sores, wounds, flu and colds. E. purpurea in modern times has been used as an ‘immunostimulant’, but is known to cause a fall in white cell count, and to be purely a placebo. Licensed for use as a Traditional Herbal Medicine, which does not require proof of efficacy, in the UK. Licensed as a Traditional Herbal Remedy in the UK (Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • A mother explaning to a doctor that her baby's medicine has been used up quickly because the whole family tried it - to encourage baby to take some. Reproduction of a drawing by B. Prance, 1923.
  • Dianthus caryophyllus L. Caryophyllaceae Carnation, clove-gilliflowers - Mediterranean Culpeper (1650) writes that ‘Clove-gilliflowers, resist the pestilence, strengthen the heart, liver and stomach, and provokes lust.’ They smell strongly of cloves, and an oil made from the petals is used in perfumery, soaps etc. The petals are sometimes used as a garnish for salads. In herbal medicine they are used to make a tonic. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Hepatica nobilis Mill. Ranunculaceae. Liverwort - not to be confused with the lichen of the same name. Distribution: North America. Liverwort (‘liver plant’): discontinued herbal medicine for disorders of the liver. The name and the use to which the Liverworts have been put medicinally is suggested, according to the doctrine of signatures, by the shape of the leaves which are three-lobed, like the liver. It is little used in modern herbalism but was employed in treating disorders of the liver and gall bladder, indigestion etc. It is highly toxic. Hepatica acutiloba was widely used for liver disorders in the 1880s, with up to 200,000 kilos of leaves being harvested per annum to make liver tonics - which eventually caused jaundice. Gerard (1633) calls it Hepaticum trifolium, Noble Liverwort, Golden Trefoile and herbe Trinity and writes: 'It is reported to be good against weakness of the liver which proceedeth from a hot cause, for it cooleth and strengtheneth it not a little. ' He adds ' Baptista Sardus[a Piedmontese physician fl. 1500] commendeth it and writeth that the chiefe vertue is in the root
  • Hepatica nobilis Mill. Ranunculaceae. Liverwort - not to be confused with the lichen of the same name. Distribution: North America. Liverwort (‘liver plant’): discontinued herbal medicine for disorders of the liver. The name and the use to which the Liverworts have been put medicinally is suggested, according to the doctrine of signatures, by the shape of the leaves which are three-lobed, like the liver. It is little used in modern herbalism but was employed in treating disorders of the liver and gall bladder, indigestion etc. It is highly toxic. Hepatica acutiloba was widely used for liver disorders in the 1880s, with up to 200,000 kilos of leaves being harvested per annum to make liver tonics - which eventually caused jaundice. Gerard (1633) calls it Hepaticum trifolium, Noble Liverwort, Golden Trefoile and herbe Trinity and writes: 'It is reported to be good against weakness of the liver which proceedeth from a hot cause, for it cooleth and strengtheneth it not a little. ' He adds ' Baptista Sardus [a Piedmontese physician fl. 1500] commendeth it and writeth that the chiefe vertue is in the root
  • Papaver somniferum L. Papaveraceae Opium Poppy Distribution: Asia minor, but has been dated to 5000BC in Spanish caves. Now grows almost everywhere. The oldest medicine in continuous use, described in the Ebers' papyrus (1550 BC), called Meconium, Laudanum, Paregoric and syrup of poppies. Culpeper (1650) on Meconium '...the juyce of English Poppies boyled till it be thick' and 'I am of the opinion that Opium is nothing else but the juyce of poppies growing in hotter countries, for such Opium as Authors talk of comes from Utopia.[he means an imaginary land, I suspect]’]. He cautions 'Syrups of Poppies provoke sleep, but in that I desire they may be used with a great deal of caution and wariness...' and warns in particular about giving syrup of poppies to children to get them to sleep. The alkaloids in the sap include: Morphine 12% - affects ?-opioid receptors in the brain and causes happiness, sleepiness, pain relief, suppresses cough and causes constipation. Codeine 3% – mild opiate actions – converted to morphine in the body. Papaverine, relaxes smooth muscle spasm in arteries of heart and brain, and also for intestinal spasm, migraine and erectile dysfunction. Not analgesic. Thebaine mildly analgesic, stimulatory, is made into oxycodone and oxymorphone which are analgesics, and naloxone for treatment of opiate overdose – ?-opioid receptor competitive antagonist – it displaces morphine from ?-opioid receptors, and constipation caused by opiates. Protopine – analgesic, antihistamine so relieves pain of inflammation. Noscapine – anti-tussive (anti-cough). In 2006 the world production of opium was 6,610 metric tons, in 1906 it was over 30,000 tons when 25% of Chinese males were regular users. The Opium wars of the end of the 19th century were caused by Britain selling huge quantities of Opium to China to restore the balance of payments deficit. Laudanum: 10mg of morphine (as opium) per ml. Paregoric: camphorated opium tincture. 0.4mg morphine per ml. Gee’s Linctus: up to 60 mg in a bottle. J Collis Browne’s chlorodyne: cannabis, morphine, alcohol etc. Kaolin and Morph. - up to 60 mg in a bottle. Dover’s Powders – contained Ipecacuana and morphine. Heroin is made from morphine, but converted back into morphine in the body (Oakeley, 2012). One gram of poppy seeds contains 0.250mgm of morphine, and while one poppy seed bagel will make a urine test positive for morphine for a week, one would need 30-40 bagels to have any discernible effect. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Papaver somniferum L. Papaveraceae Opium Poppy Distribution: Asia minor, but has been dated to 5000BC in Spanish caves. Now grows almost everywhere. The oldest medicine in continuous use, described in the Ebers' papyrus (1550 BC), called Meconium, Laudanum, Paregoric and syrup of poppies. Culpeper (1650) on Meconium '...the juyce of English Poppies boyled till it be thick' and 'I am of the opinion that Opium is nothing else but the juyce of poppies growing in hotter countries, for such Opium as Authors talk of comes from Utopia [he means an imaginary land, I suspect]’. He cautions 'Syrups of Poppies provoke sleep, but in that I desire they may be used with a great deal of caution and wariness...' and warns in particular about giving syrup of poppies to children to get them to sleep. The alkaloids in the sap include: Morphine 12% - affects ?-opioid receptors in the brain and causes happiness, sleepiness, pain relief, suppresses cough and causes constipation. Codeine 3% – mild opiate actions – converted to morphine in the body. Papaverine, relaxes smooth muscle spasm in arteries of heart and brain, and also for intestinal spasm, migraine and erectile dysfunction. Not analgesic. Thebaine mildly analgesic, stimulatory, is made into oxycodone and oxymorphone which are analgesics, and naloxone for treatment of opiate overdose – ?-opioid receptor competitive antagonist – it displaces morphine from ?-opioid receptors, and reverses the constipation caused by opiates. Protopine – analgesic, antihistamine so relieves pain of inflammation. Noscapine – anti-tussive (anti-cough). In 2006 the world production of opium was 6,610 metric tons, in 1906 it was over 30,000 tons when 25% of Chinese males were regular users. The Opium wars of the end of the 19th century were caused by Britain selling huge quantities of Opium to China to restore the balance of payments deficit. Laudanum: 10mg of morphine (as opium) per ml. Paregoric: camphorated opium tincture. 0.4mg morphine per ml. Gee’s Linctus: up to 60 mg in a bottle. J Collis Browne’s chlorodyne: cannabis, morphine, alcohol etc. Kaolin and Morph. - up to 60 mg in a bottle. Dover’s Powders – contained Ipecacuana and morphine. Heroin is made from morphine, but converted back into morphine in the body (Oakeley, 2012). One gram of poppy seeds contains 0.250mgm of morphine, and while one poppy seed bagel will make a urine test positive for morphine for a week, one would need 30-40 bagels to have any discernible effect. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Euphorbia milii Des Moul. Euphorbiaceae. Crown of Thorns - so called because of its very spiny stems. Distribution: Madagascar. The latex contains a copper-containing amine oxidase, a lectin, lipase, peroxidase, and a diamine oxidase. In vitro the latex is synergistic with ketoconazole against Candida albicans (thrush). All Euphorbia have a toxic white latex, and in Europe this has been used as a folk remedy to treat warts. It can cause skin allergies and the smoke from burning them is toxic. the genus named for Euphorbus (fl. circa 10 BC – 20 AD), the Greek physician to the Berber King Juba II (c. 50 BC – 23 AD) of Numidia, Euphorbia milii is one of the tropical spurges, with fierce, cactus-like spines, grown as a house plant. The sap of spurges is used in folk medicine for treating warts (not very effective), and, historically, as a purgative - the word spurge being derived from the French word for purgation. The sap (probably dried) was administered inside a fig because it is so corrosive that it would otherwise burn the mouth and oesophagus – a technique used today, rather more subtly, with ‘enteric coated’ medications. The sap contains a potential anti-leukaemic chemical, lasiodoplin, and is also used in drainage ditches to kill the snails which carry the parasitic trematode which causes fasciolaris. It does not kill the fish. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Scutellaria baicalensis Georgi Lamiaceae. Baikal skullcap. Distribution: China. There are several hundred species of Scutellaria, also known as skull caps, so correct identification is important - in particular from Scutellaria lateriflora an American species known as Blue skullcap. The latter is used as an abortifacient and to expel placenta by the Cherokee and for cleaning the throat by the Iroquois (Austin, 2004). Much vaunted as a treatment for rabies with unlikely statistics (1,400 cases cured by one doctor alone). Also as ‘antispasmodic, nervine, [for] chorea, convulsions, tetanus, tremors, delirium tremens, [and as a] diaphoretic and diuretic'. Toxicity symptoms include mental confusion, stupor, headache, vertigo, photophobia, dilated pupils, difficulty in micturition, bradycardia, tremulousness and languor, followed by wakefulness and restlessness (Milspaugh, 1974). Hutchens (1991) reported that it reduces sexual desire and was used for almost every nervous illness. Scutellaria baicalensis contains baicalin, baicalein and wogonin (European Medicines Agency, September 2010). It is used in Traditional Chinese Medicine for treating inflammation, cancer, bacterial and viral infections of the lungs and gut and is one of the '50 Chinese herbs' in the lists of some authors. Scutellaria lateriflora (combined with Verbena officinalis, Passiflora incarnata and the seed of Avena sativa (oats) is licensed for use in Britain as a herbal medicine for temporary relief of mild symptoms of stress such as mild anxiety and to aid sleep, based upon traditional use only. Scutellaria baicalensis is not licensed for use in the UK (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Calendula officinalis L. Asteraceae. Pot marigold, common marigold, ruds or ruddles. Calendula, because it was said to flower most commonly at the first of each month - the 'calends' (Coles, 1657). officinalis indicates that it was used in the 'offices' - the clinics - of the monks in medieval times. Annual herb. Distribution: Southern Europe. The Doctrine of Signatures, indicated that as the flowers resembled the pupil of the eye (along with Arnica, Inula and the ox-eye daisy), it was good for eye disorders (Porta, 1588). Coles (1658) writes '... the distilled water ... helpeth red and watery eyes, being washed therewith, which it does by Signature, as Crollius saith'. Culpeper writes: [recommending the leaves] '... loosen the belly, the juice held in the mouth helps the toothache and takes away any inflammation, or hot swelling being bathed with it mixed with a little vinegar.' The petals are used as a saffron substitute - ‘formerly much employed as a carminative