concept

Shop

Galleries and Reading Room

Library

Café

We’re undertaking research with website visitors to find out some more about you and what you thought about your visit. This survey will take less than 10 minutes to complete. Thank you for your time!

What brought you to our website today?

In Peptidomimetics Protocols, Wieslaw Kazmierski assembles a state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bond replacements, and enzyme inhibitors. Topics range from syntheses of unusual amino acids, to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of otherwise labile peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed. Peptidomimetics Protocols is the first book devoted to the practical synthetic preparation of peptide mimetics. Written by both academic and industrial synthetic organic and medicinal chemists, this book provides highly practical synthetic procedures for the generation of key peptide mimetics, and so immediately becomes a must-have desk reference and guide for all medicinal and pharmaceutical chemists engaged in the discovery and development of pharmaceuticals today.

Methods in Molecular Medicine™

Springer eBooks

Peptidomimetics Protocols / edited by Wieslaw M. Kazmierski.

Providing experimental methods and protocols for performing pheromone research in a variety of organisms ranging from invertebrates to vertebrates, Pheromone Signaling: Methods and Protocols covers a wide spectrum of experimental approaches necessary for handling pheromone molecules, measuring receptor response and neural activation, and analyzing behavioral output. A great deal of progress has been made in understanding the molecular mechanisms underlying pheromone action, largely due to the discovery of receptor genes, the advancement of imaging techniques, and key multi-disciplinary approaches including aspects of organic chemistry, biochemistry, molecular biology, electrophysiology, and behavioral science. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Pheromone Signaling: Methods and Protocols details the key methodologies utilized in laboratories all over the world, making them accessible to those who want to begin investigation in the area of pheromone research.

Methods in Molecular Biology, Methods and Protocols

XV, 399 pages 74 illustrations, 30 illustrations in color : online resource.

Pheromone Signaling : Methods and Protocols / edited by Kazushige Touhara.

Neuromethods

Animal Models of Neurological Disease, I : Neurodegenerative Diseases / edited by Alan A. Boulton, Glen B. Baker, Roger F. Butterworth.

Classical methods for microbial strain engineering, used to improve the production of bioproducts, have serious drawbacks and have been found to be unsuitable for complex strain development applications. In Strain Engineering: Methods and Protocols, powerful new genetic engineering-based strain engineering methods are presented for rational modification of a variety of model organisms. These methods are particularly powerful when utilized to manipulate microbes for which sequenced and annotated genomes are available. Collectively, these methods systematically introduce genome alterations in a precise manner, allowing the creation of novel strains carrying only desired genome alterations. In the first section, E. coli-based bacterial strain engineering strategies are reviewed, while the second section presents analogous microbial engineering strategies for eukaryotic cells using the yeast Saccharomyces cerevisiae as a model. The third section covers examples of the proliferative adaptations of these base technologies to strain engineer industrially important prokaryotic or eukaryotic microbial systems. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Strain Engineering: Methods and Protocols serves as an ideal guide to scientists in academia, pharmaceutical science, and biotechnology who perform microbial strain engineering.

XI, 480 pages 83 illustrations, 2 illustrations in color : online resource.

Strain Engineering : Methods and Protocols / edited by James A. Williams.

Genomic imprinting, the process by which the non-equivalence of the paternal and maternal genomes is established, has been fascinating us for over three decades and has provided many emerging scientists with the chance to hit their stride in a frontier posing many unexpected questions and even more surprising answers. In Genomic Imprinting: Methods and Protocols, experts in the field provide a survey of the technologies that are being applied to advance the study of imprinting. This detailed volume features new technologies that are accelerating the pace of discovery of imprinted genes and characterization of their epigenetic profile, bioinformatic procedures for prediction and comparative analyses of imprinted genes, as well as methods in embryology and basic molecular biology that have been employed for many years, some appearing in new versions for small cell numbers. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Genomic Imprinting: Methods and Protocols will aid scientists in unveiling both much awaited answers and all-new questions to keep this vital field busy for many exciting years to come.

XI, 297 pages 40 illustrations, 19 illustrations in color : online resource.

Wellcome uses cookies.

SpringerLink (Online service)

Works

Peptidomimetics Protocols / edited by Wieslaw M. Kazmierski.

Pheromone Signaling : Methods and Protocols / edited by Kazushige Touhara.

Animal Models of Neurological Disease, I : Neurodegenerative Diseases / edited by Alan A. Boulton, Glen B. Baker, Roger F. Butterworth.

Strain Engineering : Methods and Protocols / edited by James A. Williams.

Genomic Imprinting : Methods and Protocols / edited by Nora Engel.

Today’s opening times

Wellcome uses cookies.

SpringerLink (Online service)

Works

Peptidomimetics Protocols / edited by Wieslaw M. Kazmierski.

Pheromone Signaling : Methods and Protocols / edited by Kazushige Touhara.

Animal Models of Neurological Disease, I : Neurodegenerative Diseases / edited by Alan A. Boulton, Glen B. Baker, Roger F. Butterworth.

Strain Engineering : Methods and Protocols / edited by James A. Williams.

Genomic Imprinting : Methods and Protocols / edited by Nora Engel.

Wellcome Collection

Today’s opening times