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Contemporary science series

Medical Heritage Library

Evolution and disease / by J. Bland Sutton ; with 136 illustrations.

x, 178 pages : illustrations (some color) ; 24 cm

The epigenome : molecular hide and seek / edited by S. Beck and A. Olek.

Understanding the human genome project / Michael A. Palladino.

We are entering a particularly fruitful period in evolutionary genetics, as rapid technological progress transforms the investigation of genetic variation within and between species. Molecular Methods for Evolutionary Genetics is a collection of advanced molecular biology protocols and general overviews intended to represent the essential methods currently bringing evolutionary genetics to fruition. Divided into six thematic sections, this volume covers methods for characterizing genomes, diverse approaches to enrich DNA for subsets of the genome prior to sequencing, and state-of-the-art protocols for sampling genetic variation for genetic mapping studies and population genetic studies (RAD sequencing, Sequenom, microarrays, etc.). The volume concludes by focusing on methods to study candidate genes, from obtaining their sequences and analyzing their transcripts to experimentally manipulating their activities in vivo. Written in the highly successful Methods in Molecular Biology™ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Molecular Methods for Evolutionary Genetics serves as a rich resource to biologists interested in evolution, whether they be specialists or beginners in molecular biology.

Methods in Molecular Biology, Methods and Protocols

Springer eBooks

XVI, 503 pages 81 illustrations, 4 illustrations in color : online resource.

Molecular Methods for Evolutionary Genetics / edited by Virginie Orgogozo, Matthew V. Rockman.

Encyclopedia of medical genomics and proteomics / edited by Jurgen Fuchs, Maurizio Podda.

Arising from firm foundations laid by mathematical population genetics, clinical genetics, and statistical epidemiology, genetic epidemiology attempts to identify the many components of risk attributable to genes, environments, and interactions, and the course of its research can follow many diverse paths. In Genetic Epidemiology, the success of genome-wide association studies in their identification of hundreds of disease susceptibility loci has inspired renowned experts to contribute thorough methodologies, which aim to bring together bioinformaticians, geneticists, clinicians, statisticians, and epidemiologists in the study of this vital field. The volume opens with chapters covering the basics; however, it quickly moves on to coverage of more specialist topics such as twin studies, Mendelian randomization, genetic association studies, more advanced areas, as well as case studies. As a part of the highly successful Methods in Molecular Biology™ series, this work provides the detailed description of the application and analysis of the most commonly employed methods that are necessary for a firm grounding in the field. Authoritative and cutting-edge, Genetic Epidemiology aims to provide a basic framework for crucial interdisciplinary communication and understanding suited to newcomers to the field as well as experienced researchers and graduate level students.

Genetic Epidemiology / edited by M. Dawn Teare.

AAAS selected symposium

Genetic diseases and developmental disabilities : aspects of detection and prevention / edited by Tamah L. Sadick and Siegfried M. Pueschel.

4 unnumbered pages, xii, 2 unnumbered pages, 214 pages, 2 unnumbered pages : illustrations ; 23 cm

A practical essay on the club-foot, and other distortions in the legs and feet of children, intended to show under what circumstances they are curable, or otherwise : with thirty-one cases that have been successfully treated by the method for which the author has obtained the King's patent, and the specification of the patent for that purpose, as well as for curing distortions of the spine, and every other deformity that can be remedied by mechanical applications / by T. Sheldrake.

Voices of modern biomedicine

xiv, 145 pages : black and white portraits ; 24 cm.

Genetics & health : compilation of edited interviews conducted by the History of Modern Biomedicine Research Group, Queen Mary University of London / edited by E M Tansey and A Zarros.

The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences. Those tandem repeats located as codons within open reading frames encode amino acid runs, such as polyglutamine and polyalanine. Tandem repeats have not only been implicated in biological evolution, development and function but also in a large collection of human disorders. In Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols, expert researchers in the field detail many methods covering the analysis of tandem repeats in DNA, RNA and protein, in healthy and diseased states. This will include molecular genetics, molecular biology, biochemistry, proteomics, biophysics, cell biology, and molecular and cellular approaches to animal models of tandem repeat disorders. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoratative and Practical, Tandem Repeats in Genes, Proteins, and Disease: Methods and Protocols aids scientists in continuing to study the unique methodological challenges that come from repetitive DNA and poly-amino acid sequences.

XI, 258 pages 55 illustrations, 23 illustrations in color : online resource.

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Evolution and disease / by J. Bland Sutton ; with 136 illustrations.

The epigenome : molecular hide and seek / edited by S. Beck and A. Olek.

Understanding the human genome project / Michael A. Palladino.

Molecular Methods for Evolutionary Genetics / edited by Virginie Orgogozo, Matthew V. Rockman.

Encyclopedia of medical genomics and proteomics / edited by Jurgen Fuchs, Maurizio Podda.

Genetic Epidemiology / edited by M. Dawn Teare.

Genetic diseases and developmental disabilities : aspects of detection and prevention / edited by Tamah L. Sadick and Siegfried M. Pueschel.

Genetics & health : compilation of edited interviews conducted by the History of Modern Biomedicine Research Group, Queen Mary University of London / edited by E M Tansey and A Zarros.

Tandem Repeats in Genes, Proteins, and Disease : Methods and Protocols / edited by Danny M. Hatters, Anthony J. Hannan.

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Evolution and disease / by J. Bland Sutton ; with 136 illustrations.

The epigenome : molecular hide and seek / edited by S. Beck and A. Olek.

Understanding the human genome project / Michael A. Palladino.

Molecular Methods for Evolutionary Genetics / edited by Virginie Orgogozo, Matthew V. Rockman.

Encyclopedia of medical genomics and proteomics / edited by Jurgen Fuchs, Maurizio Podda.

Genetic Epidemiology / edited by M. Dawn Teare.

Genetic diseases and developmental disabilities : aspects of detection and prevention / edited by Tamah L. Sadick and Siegfried M. Pueschel.

Genetics & health : compilation of edited interviews conducted by the History of Modern Biomedicine Research Group, Queen Mary University of London / edited by E M Tansey and A Zarros.

Tandem Repeats in Genes, Proteins, and Disease : Methods and Protocols / edited by Danny M. Hatters, Anthony J. Hannan.

Stay in the know

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