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Osteoclast degrading bone (green and

yellow). The osteoclast cell membrane (pink) surrounds the cytoplasm which contains the ingested bone matrix (pale blue spots). The cell tunnels through the bone matrix in a worm-like manner forming the black resorption trail. Biomedical Image Awards 2005.

Osteoclast resorbing bone

Fluorescently stained mouse colonic villi. The tips of the villi have been cropped away to show the internal morphology. The red stain shows actin in the micrivilli that cover the surface of each villus. Cell nuclei are labelled blue.

Villi in the colon

3D reconstruction of fluorescently stained mouse small intestinal villi. The green stain shows actin in the micrivilli that cover the surface of each villus. Cell nuclei are labelled blue.

Villi in the small intestine

A deconvolved wide-field fluorescence microscope image of human HeLa cancer cells undergoing cytokinesis (cell division). The red fluorescence is the microtubules of the cytoskeleton. The white is actin. The blue is DNA (DAPI stain). The green is Aurora B, a protein kinase involved in the polymerisation/depolymerisation of the microtubules during mitosis and cytokinesis. The yellow area is the overlap between the red and the green fluorescence.

Human HeLa cancer cells, cytokinesis

A deconvolved wide-field fluorescence microscope image of human HeLa cancer cells undergoing cytokinesis (cell division). The chromosomes are red (DAPI stain for DNA). The microtubules of the cytoskeleton/spindle are purple, and the actin white. The green is Aurora B, a protein kinase involved in the polymerisation/depolymerisation of the microtubules during mitosis and cytokinesis.

Fast muscle fibres form the deep layers of muscle in the zebrafish myotomes. Fast fibres are stained green and their nuclei red..Fast fibres contract quickly but also tire quickly. In contrast slow fibres contract slowly but can keep going for a long time.

Fast muscle fibres in zebrafish myotomes

3D reconstruction of fluorescently stained mouse small intestinal villi

villi of small intestine

Cultured colon cancer cells showing the nuclei stained with DAPI in blue, the actin cytoskeleton in red and plectin (isoform 1e) in green. Plectin binds to actin and helps regulate the activity of the cytoskeleton.

Colon cancer cells

Slow muscle fibres form the surface layers of muscle fibres in the zebrafish myotomes. Slow fibres are stained blue and their nuclei red. Slow fibres contract slowly but can keep going for a long time. In contrast, fast fibres contract quickly but also tire quickly.

Slow muscle fibres in zebrafish myotomes

Single muscle fibre from zebrafish. The three nuclei seen here are typical of the multiple nuclei found in muscle cells.

Single muscle cell

Colour-enhanced transmission electron microscope image of a mast cell full of histamine granules (pink). Histamine is released as part of an allergic reaction. 
The diameter of the cell is approx. 8.4 micrometres. Biomedical Image Awards 2005.

Mast cell showing histamine granules

New bone growth (pink, blue and yellow) within a porous bioceramic bone graft substitute (dark framework). Biomedical Image Awards 2005.

New bone growth within a bioceramic bone substitute

Micrograph shows microtubules in vitro. Microtubles make up the cytoskeleton and provide structural support within cells. This image of microtubels was captured as part of an in vitro assay using rhodamine labelling to determine microtubule polymerization and viability. Imaging was carried out on a DeltaVision Restoration Microscopy System.

Microtubles in vitro

Cultured colon cancer cells showing the nuclei stained with DAPI in blue, the actin cytoskeleton in red and plectin (isoform 1e) in green. Plectin interacts with the actin, regulating its behaviour. Actin stress fibres are visible radiating through the cell.

Molecular model of human enzyme HMG-CoA reductase. This enzyme catalyses the first step in the cholesterol biosynthesis pathway and is inhibited by statins. The four protein subunits are shown in blue, turquoise, yellow and red. Pink highlights the CoA and green, the molecule that will be released from the enzyme as mevalonate. Biomedical Image Awards 2005.

HMG-CoA reductase

3D reconstruction of fluorescently stained mouse small intestinal villi viewed from above. The red stain shows actin in the micrivilli that cover the surface of each villus. Underlying cell nuclei are labelled blue.

The stages of cell division showing the DNA in blue, the tubulin in green and the kinetochores in pink. Starting with interphase at the top and progressing anticlockwise, the stages shown are: prophase, prometaphase (incomplete chromosome attachment), metaphase (chromosomes all attached and aligned), early anaphase (chromosome separation), anaphase and telophase. Biomedical Image Awards 2005.

Human cells showing the stages of cell division

<I>Drosophila</I> oocytes stained for actin (purple) and DNA (orange). Each chain of oocytes develops from basal germ stem cells. Biomedical Image Awards 2005.

Drosophila ovaries stained for actin/purple and DNA/orange.

Cardiac muscle stained for mitochondria. Mitochondria provide the energy to power contraction of the muscle.

Transgenic zebrafish embryos expressing green fluorescent protein in the muscle precursor cells (myotomes). The green fluorescence comes from an alpha-actin-GFP transgene acting in these living, one day old embryos. Biomedical Image Awards 2005.

Zebrafish embryos with green fluorescent myotomes

Fluorescent micrograph showing the localisation of paneth cells in the mouse small intestine. The tissue was stained with an antibody against lysozyme (green), an enzyme that aids in digestion and is abundant in Paneth cells. Paneth cells are found along the intestine and their main function is in the secretion of lysozyme they are also thought to have a protective role as they are located in small intestinal crypts adjacent to stem cells, which renew the epithelial lining suggesting they play a role in protecting this cell renewal process. Rhodamine phalloidin was used to label F-actin a fibrous muscle protein (red) and DAPI to highlight the cell nuclei.

Mouse small intestine

Muscle fibres in zebrafish myotomes. Fast fibres are stained blue and a single slow fibre is labelled green with green fluoresceent protein. The nuclei are stained red.

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Osteoclast resorbing bone

Villi in the colon

Villi in the small intestine

Human HeLa cancer cells, cytokinesis

Human HeLa cancer cells, cytokinesis

Fast muscle fibres in zebrafish myotomes

villi of small intestine

Colon cancer cells

Slow muscle fibres in zebrafish myotomes

Single muscle cell

Mast cell showing histamine granules

New bone growth within a bioceramic bone substitute

Microtubles in vitro

Colon cancer cells

HMG-CoA reductase

Villi in the small intestine

Human cells showing the stages of cell division

Drosophila ovaries stained for actin/purple and DNA/orange.

Cardiac muscle stained for mitochondria. Mitochondria provide the energy to power contraction of the muscle.

Zebrafish embryos with green fluorescent myotomes

Mouse small intestine

Fast and slow muscle fibres in zebrafish myotomes

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More filters

Active filters:

Osteoclast resorbing bone

Villi in the colon

Villi in the small intestine

Human HeLa cancer cells, cytokinesis

Human HeLa cancer cells, cytokinesis

Fast muscle fibres in zebrafish myotomes

villi of small intestine

Colon cancer cells

Slow muscle fibres in zebrafish myotomes

Single muscle cell

Mast cell showing histamine granules

New bone growth within a bioceramic bone substitute

Microtubles in vitro

Colon cancer cells

HMG-CoA reductase

Villi in the small intestine

Human cells showing the stages of cell division

Drosophila ovaries stained for actin/purple and DNA/orange.

Cardiac muscle stained for mitochondria. Mitochondria provide the energy to power contraction of the muscle.

Zebrafish embryos with green fluorescent myotomes

Mouse small intestine

Fast and slow muscle fibres in zebrafish myotomes

Stay in the know

Wellcome collectionWellcome Collection

Finding us:

Opening times:

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Wellcome collection