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Trichuris muris is a parasitic nematode affecting mice. Following ingestion, T. muris eggs hatch in the large intestine where they develop into adults. The anterior end of the worm burrows into the lining of the gut, leaving the posterior end protruding into the lumen of the gut. The worms mate in this orientation, and the resulting eggs are released in to the gut lumen and shed faecally.
- David Goulding, Wellcome Trust Sanger Institute
Liver of a DEN (Diethylnitrosamine)-treated rat. DEN is a toxic chemical which quickly induces liver cirrhosis followed by HCC (Hepatocellular carcinoma, a primary liver cancer). Cirrhosis is an end result of fibrosis, the scarring of liver tissue. Fibrosis is caused by the overproduction of collagen, a component of the connective tissue forming the liver. To grade the amount of cirrhosis present in a liver sample, collagen is made visible using the dye sirius red. Under polarized light, collagen is observed as the golden to red color as shown in this image.
- Tabea Hohensee
Confocal micrograph of Bacillus subtilis. Bacillus subtilis is a Gram-positive, rod-shaped bacterium, commonly found in soil. Fluorescent proteins (TagRFP-T, sfGFP, TagBFP, mKate2 and mOrange2), time-lapse confocal microscopy and biophysical models are being used to understand the organization of bacterial biofilms.
- Fernan Federici & Jim Haseloff