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Cellular architecture of normal human skin imaged by whole mount tissue microscopy. Human skin has a rich network of white blood cells (specifically dendritic cells, T cells and macrophages) which form sheaths around blood vessels. This image was taken directly beneath the junction that joins the dermal and epidermal layers of the skin (dermo-epidermal junction). At this level, the capillary network (stained for CD31; red) is visualised against a lawn of autofluorescent dermal papillae (finger-like projections of the dermis; green) scattered with dendritic cells (stained for CD11c; green) and macrophages (stained for LYVE-1; blue). This normal cellular architecture is grossly disrupted in diseased skin (see related images). Scale bar (white) represents 200 micrometres.
- Muzlifah Haniffa, Newcastle University
Human neural stem cells stained for nestin (red). Nestin is a type of intermediate filamant protein that is used as a marker of neural stem cells. The blue dots are the cell nuclei stained with DAPI. Neural stem cells can be made to develop into cells found in the central nervous system; neurons, astrocytes and oligodendrocytes.
- Yirui Sun