Fever : its pathology and treatment by antipyretics / by Hobart Amory Hare.

  • Hare, H. A. (Hobart Amory), 1862-1931.
Date:
1891
Catalogue details

Licence: Public Domain Mark

Credit: Fever : its pathology and treatment by antipyretics / by Hobart Amory Hare. Source: Wellcome Collection.

Provider: This material has been provided by The University of Leeds Library. The original may be consulted at The University of Leeds Library.

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    The sweiiting, sometimes produced in excessive amounts, may prove a just cause for tlie non-employ- ment of the drug in typhoid fever. Numerous cases have come under the author's notice where this state existed, and Osier has noted that the profusion of the sweat may be so great as to utterly prohibit its use. By far the most exhaustive study of the effects of antifebrin in typhoid fever that we have seen is that of Giittmann,! who treated no less than 81 cases with the drug, giving 7 grains night and morning, except at about the twelfth or fourteenth day, when one dose was suf- ficient. He thinks that small, repeated doses are useless and without any effect, yet so confident is he of the power of the drug in doing good, if used properly, that he thinks it quite as efficacious as the cold bath, and better, in typhoid fever, than any other remedy of its class. The reason for Guttmann's preference for antifebrin to antipyrin is found in the diminutive dose of the former as compared to that of the latter, for he states that he discovered tliat it required as much as 60 or 70 grains of antipyrin twice a day to produce the effects seen after the use of 7 grains of antifebrin, night and morn- ing. He also noted that the apyrexia of antipyrin only- lasted about four hours, while that of antifebrin was of much longer duration. On the other hand, it is claimed by Secretan^ that the reverse is the case, and that antipyrin is far superior to antifebrin in the permanence of its action. Demmes also makes a similar assertion, and the writer, from his own observations, is inclined to agree with him. Very ' Berliner klin. Wochensclirift, 1887, p. 942. ' Revue Me'ilicale de la Suisse Romande. 1886. ' Internationale KUin. Ruudschau, No. 4, 1888. 5 E