The effect of varying tonicity on the anaphylactic and other reactions of plain muscle / by H.H. Dale.

  • Dale, Henry H. (Henry Hallett), 1875-1968.
Date:
[191 ?]
Catalogue details

Licence: Public Domain Mark

Credit: The effect of varying tonicity on the anaphylactic and other reactions of plain muscle / by H.H. Dale. Source: Wellcome Collection.

    18/26 (page 532)
    the same osmotic pressure as Ringer’s solution, acts as a diluent like distilled water (fig. 11). This, again, is in accordance with the supposition that the effect is due to change in the tonicity of the solution, since urea, to which the cell-membranes are per¬ fectly permeable, is osmotically indifferent where living cells are concerned. 11 m itrr rrrr m rr 111111 m 111111»rtrrrrm Fig. 12. Horn of Uterus of Virgin Cat in 250 cc. Ringer II At A, 0.002 mgm. adrenine. R, change to fresh Ringer. At B — 1 cc. 25 per cent NaCl (raising NaCl concentration from 0.9 to 1 per cent). A fall in the tonicity of the bathing-fluid, if sufficiently large and sudden, is itself an efficient stimulus. Thus the addition of 30 cc. of distilled water to a bath containing 250 cc. of Ringer’s solution usually provokes a contraction of the plain muscle sus¬ pended therein. A more marked contraction is produced by adding 50 cc. of water, which reduces the saline concentration