Study XXI : the immediate effect of repeated doses of theobromin sodium salicylate and theocin on renal function in acute experimental nephritis / R. Fitz, M.D. Boston.

  • Fitz, Reginald, 1885-1953.
Date:
1914
Catalogue details

Licence: In copyright

Credit: Study XXI : the immediate effect of repeated doses of theobromin sodium salicylate and theocin on renal function in acute experimental nephritis / R. Fitz, M.D. Boston. Source: Wellcome Collection.

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    series. There was no definite increase in nitrogen excretion, and during the last period a diminution. The most striking feature, however, was the steady decrease in phenolsulphonephthalein elimination during the entire time of observation. In chromate nephritis, therefore, the imme¬ diate effect of purin diuretics was to produce a slight diuresis of water and salt, to have little effect on the excretion of nitrogen and to hinder that of phenolsulphonephthalein. If a large enough amount of drugs were given, the kidney was more easily fatigued than in normal or uranium animals, as shown by a greater lessening in the excretion of all the substances studied. In addition a series of experiments with cantharidin nephritis was attempted. When sufficient amount of the poison was given to produce outspoken lesions, it was found that the animals became anuric and failed to react to the diuretics, confirming the observations of TIellin and Spiro,15 Schlayer and Hedinger17 and Schlayer and Takayasu.18 If lesser amounts were injected, the anatomical and functional conditions of the kidney were so little changed as to make the observations of no value. These experiments, therefore, have been discarded. On the whole, in normal animals the immediate effect of injections of theobromin sodium salicylate and theocin was to produce an increased outflow of urine, sodium chlorid and to a less extent of nitrogen and phenolsulphonephthalein. After repeated small doses of the drug were given the kidney became fatigued and excreted these substances in lesser amounts. In animals suffering from uranium nephritis of varying intensity a similar immediate response to these diuretics was obtained except that the kidney became more easily fatigued. In chromium nephritis, on the other hand, while the kidney responded to the theobromin sodium sali¬ cylate and theocin by increasing the output of water and chlorid, yet the excretion of nitrogen remained almost constant and that of phenolsul¬ phonephthalein diminished. After large amounts of the drugs had been injected, the signs of renal fatigue were more pronounced than in uranium nephritis or normal animals as the water, chlorid, nitrogen and phenolsulphonephthalein excretions diminished with greater rapidity. Mosenthal and Schlayer21 have demonstrated differences in renal fatigability to repeated injections of caffein and sodium chlorid in uranium and chromate nephritis. In these experiments following repeated injections of purin diuretics the kidneys became more easily fatigued in relation to excretion of the substances studied in chromate nephritis than in uranium nephritis or normally. Thus these observa¬ tions are to a certain extent confirmatory of previous work.