Type I diabetes, islets of Langerhans glucagon secretion

  • Anne Clark, University of Oxford
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Type I diabetes, islets of Langerhans glucagon secretion. Anne Clark, University of Oxford. Attribution 4.0 International (CC BY 4.0). Source: Wellcome Collection.

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A photomicrograph of a section through the pancreas of a patient who has had Type I (early onset) diabetes for 40 years. The section has been immunolabelled for glucagon (brown). It shows how the islet shape has become distorted (imploded) as a result of loss of beta-cells in the acute automimmune destructive phase of the disease: the islet is fliled with non-beta-cells.

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