The influence of cocaine, atropine, and caffeine on the heart and bloodvessels / by H.G. Beyer.

  • Beyer, Henry Gustav, 1850-1918.
Date:
1885
Catalogue details

Licence: Public Domain Mark

Credit: The influence of cocaine, atropine, and caffeine on the heart and bloodvessels / by H.G. Beyer. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    Time P.M. Temp. Total Outflow From. to. Ceut. outflow. p. miu. 35 37 63 31.5 37 89 83 41.5 39 41 77 38.5 41 43 66 33 43 45 18.5° 45 22.5 45 47 38.5 19.2 47 49 32 16 49 51 27 13.5 61 53 28.5 14.2 53 55 26 13 55 57 28.5 12.2 57 59 18.5 24.5 12.2 59 6.01 24 12 The circulatin.? fluids were supplied to the heart at the time mentioned on the same line in first column. Experiment ended. Experiment XXVH—April 22, 1885. Terrapin 2010. Ringer's saline. Cafleine solution which was injected was a saturated solution of cart'einuni bro- midum in Ringer's saline. Infiow canulas in right and left aorta. Arterial pres- sure 20 cm. Outflow canula in sinus. Venous pressure 0. Brain and spinal cord destroyed. Interrupted pressure used. The circulating fluids were supplied to the vessels at the time mentioned on the same line in second column. Terrapin in box. Time P. M. Temp. Total Outflow From to Cent. outflow. p. min. o. 1.0 OL OO 00 1 9 OO o / /CO 19 f; oi oy op; 19 QQ oy tti 09 11 1 L 4-1 ±K ^i) OU 19 45 4.7 23 11.5 47 49 20 10' 49 52 31 10.3 52 54 24 12 54 56 28 14 56 58 20 10 58 4.00 18 9 4.00 02 16.5 8.25 02 04 33 16.5 04 06 34 17 06 08 25 12..5 08 10 25 12.5 10 12 32 16 12 14 32 26 14 16 52 26 16 18 27 13.5 18 20 15 7.5 20 22 25 12.5 22 24 30 15 24 26 25 13.5 26 28 25 12.5 28 30 30 15 30 33 31 10.3 33 35 33 16.5 35 37 25 12.5 37 39 24 12 39 42 35 11.6 42 48 68 11.3 49 52 37 12.3 52 54 70 35 54 56 74 37 On caffeinized saline. On normal saline. Injected 20 minims of caffeinized saline. Injected 20 minims of caffeinized saline. Injected 20 minims of caffeinized saline. Injected 23 minims of caffeinized saline. On caffeinized saline. Experiment discontinued. The first observation with caffeine in this experiment was evidently followed by diminished outflow, which might have been due to a contrac- tion of the arterioles. Thinking that perhaps very small doses might