Establishing tolerance for the tubercle bacillus / by Samuel G. Dixon.

  • Samuel Gibson Dixon
Date:
1890
Catalogue details

Licence: Public Domain Mark

Credit: Establishing tolerance for the tubercle bacillus / by Samuel G. Dixon. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    [From the Medical and Surgical Reporter, September 6, 1S90.] ESTABLISHING TOLERANCE FOR THE TUBERCLE BACILLUS. BY SAMUEL G. DIXON, M. D., PROFESSOR OF BACTERIOLOGY, ACADEMY OF NATURAL SCIENCES, PHILADELPHIA. In the Medical News, October 19, 1889, I advanced the idea that, to overcome infec- tion by tuberculosis it would probably be necessary to produce a tolerance to the action of the tubercle bacillus and advanced the following hypotheses: First. It is possible that, by a thorough filtering out of bacilli from tubercular material, a filtrate might be obtained and attenuated, so that by systematic inocula- tions a change might be produced in living animal tissues that would enable them to resist virulent tubercle bacilli. Second. To bring about a chemical or physical change in living tissues that would resist tubercular phthisis, it is possible that inoculations with the bacillus would have to be made; yet, before this could be done, the power of the virulent bacilli would have to be diminished ; otherwise the result would be disastrous. I also stated that I had met with success in preventing subsequent susceptibility to phthisis by inoculating animals with what I believed to be an unusual form of the