Researches in clinical physiology / by Sir Almroth E. Wright.

  • Wright, Almroth, 1861-1947.
Date:
1943
Catalogue details

Licence: In copyright

Credit: Researches in clinical physiology / by Sir Almroth E. Wright. Source: Wellcome Collection.

    20/178 (page 8)
    ERPT FROM A PAPER ENTITLED “A STUDY OF THE INTRAVASCULAR COAGULATION PRODUCED BY THE IN- JECTION OF WOOLDRIDGE’S TISSUE-FIBRINOGEN” (Reprinted from the ‘ Proceedings Royal Irish Academy ’, 3rd Series, vol. 2, 1893) The following experiment shows the sequence of events. Dog 119.—The acetic acid precipitate from a fresh extract of testicles was care- fulljT washed, and a thin solution was then made in 1 per cent. Na2C03, and was liltered through calico, but not through paper. Cannulae were inserted into the external jugular vein and into the carotid. Samples of a few c.c. each time were withdrawn from the carotid to test the condition of coagulability of the blood, and an assistant took down in writing from my dictation (a) the times at which the samples were withdrawn ; (b) the times at which injections of tissue-fibrinogen were made into the jugular vein ; and (c) the reports 1 made at intervals of about a minute upon the condition of coagulability in the various samples. Sample No. 1.-—Withdrawn 5.43 p.m. ; begins to clot, 5.46 ; almost solid, 5.47 ; can invert, 5.51. Coagulation time, 8 minutes. Ran in 10 c.c. of tissue-fibrinogen solution, 5.43 p.m. Sample No. 2.—Withdrawn 5.44 ; liquid, 60 minutes afterwards. Coagulation time, longer than 60 minutes. Ran in 10 c.c. more of tissue-fibrinogen solution, 5.44|. Sample No. 3.—Withdrawn 5.45 ; liquid, 1 hour afterwards. Coagulation time, longer than 60 minutes. Sample No. 4.—Withdrawn 5.461 ; liquid, 1 hour afterwards. Coagulation time, longer than 60 minutes. Sample No. 5.—Withdrawn 5.48 ; liquid, 1 hour afterwards. Coagulation time, longer than 60 minutes. Ran in 10 c.c. more solution, 5.48. Sample No. 6.—Withdrawn 5.50 ; still liquid, 5.53 ; can invert. 5.58 p.m. Coagulation time, 8 minutes. Sample No. 7.—Withdrawn 5.51 ; liquid, 5.53 ; clot begins, 5.55 ; half solid, 5.57 ; solid, can invert, 6.4 p.m. Coagulation time, 13 minutes. Ran in 10 c.c. more, 5.54. Sample No. 8.—Withdrawn 5.53 ; half solid, 5.59 ; solid, 6 p.m. Coagulation time, 7 minutes. Ran in 10 c.c. more, 5.54. Sample No. 9.—5.55 ; solid at 6 p.m. Coagulation time, 5 minutes. Ran in 10 c.c. more solution at 5.56. Sample No. 10.—Withdrawn 5.56 ; solid at 6 p.m. Coagulation time, 4 minutes. Ran in 10 c.c. more.