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Human metaphase, translocation, cosmid probe

Wessex Reg. Genetics Centre

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Credit: Human metaphase, translocation, cosmid probe. Credit: Wessex Reg. Genetics Centre. Attribution 4.0 International (CC BY 4.0)

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Human chromosomes at metaphase, highlighted with fluorescent probes that bind to specific sequences of DNA. This cell is from the amniotic fluid of a patient with an unbalanced translocation between chromosomes 4 and 9, t(4,9). The bcr cosmid (red) is present on both chromosome 9 homologues, and also at the distal tip of the short arm of the der(4) - chromosome 4. Image by Dr John Crolla.


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