B.T.E. & S+ Experiments

File contains handwritten and typed papers and test results relating to experiments with B.T.E. & S+ carried out at Yale. Details include:

Tabulated results from an isolated Guinea Pig Ileum experiment dated 2 June 1956 and results from ganglion experiments performed on 21 and 30 December 1955.

Summary of B.T.E Ganglia experiment results performed at Yale (experiments BTE.9 to BTE18) and summary results tables for experiments BTE13 to BTE18 performed on various dates between 23 May 1955 and 21 June 1955.

Typed summary (undated) of the experiments performed on chloralose cats and rat diaphragms and a typed summary table of the results from experiments BTE9 to BTE18.

A table and supporting papers showing the solution compositions for the experiments; BTE9 to BTE18; C10, Curare and C6; BDE11 and BDE12; and BDM10.

Section titled, "S+ & N+ C6" containing graphs and written notes about experiment results for experiments that took place between 31 March 1955 and 18 January 1956 (covering experiments SU3 to SU17 and BTE29).

Section titled, "BTE in Ganglia" containing graphs and written notes about experiment results for experiments that took place between 21 April 1955 and 17 June 1955 (covering experiments SU18 to SU20, BTE13 to BTE44, and C6).

Section titled, "BTE frog rectus" containing graphs and written notes about experiment results for experiments that took place between 5 May 1955 (experiment BTE31)and 9 May 1955 (experiment BTE33).

Section titled, "BTE Other Preparations" containing graphs and written notes about experiment results for experiments that took place between 3 May 1955 and 21 June 1955 (covering experiments BTE9 to BTE43, Curare and C10).

Section titled, "Results S+ & N+ C6" containing tables, tracings and written notes about experiment results for experiments that took place between 31 March 1955 and 10 May 1955.

Section titled, "Results BTE Series" containing tables of experiment results for experiments that took place between 21 April 1955 and 23 May 1955 (experiments BTE9 to BTE16).

A section without title containing; the tentative Pharmacology 101 schedule for 1955 (showing dates of lectures and laboratories, subjects and staff members in February and March 1955); a list of seminars from February to May 1955 and related groups; printed details of the scientific backgrounds of the lecturers including Vane; a list of probable class experiments; and tentative schedule for chemist's classes.

Section titled, "Apparatus & Drugs for Classes" containing; equipment purchase list for students; apparatus needed for each specific class; list of possible class experiments; apparatus and drugs required for each specific class (6 lists in total for classes beginning 18 February 1955 and running to the end of April 1955); and a list of animals, apparatus and drugs needed for the chemists' classes (7 lists in total for classes beginning 14 February 1955 and running to 30 March 1955).

Section titled, "Class Experiments (Medical Students)" containing; a paper on the effects of drugs on the cardio-vascular system (dated 18 February 1955); a paper titled, "the effects of drugs on the respiration" (two copies); a list of the apparatus and drugs neede for the class on ganglia; a paper titled, "ganglionic transmission and the effects of blocking agents"; a paper titled, "the effects of drugs on the isolated rabbit intestine"; a paper titled, "the bioassay of histamine"; a paper titled, "perfusion of the frog heart"; a paper titled, "the actions of drugs on the frog rectus muscle"; a paper titled, "the chemotherapy of trypanosomiasis in mice"; and a paper titled, "the antagonistic effect of 2 3-Dimercaptopropanol (BAL) (Dimercaprol) on the acute toxicity of oxophenarsine hydrochloride ("Mapharsen")

Section titled, "Class Experiments (Chemists)" containing the following papers:

A description of the composition of the class on 16 February 1955, including a class experiment (analeptic effects of picrotoxin in mice anaesthatized with nembutal), and demonstrations (morphine/nalline antagonism in rabbits, the "hot spot" test for analgesic activity in rats, and strychnine/mephenesin antagonism in mice).

A description of the composition of the class on 23 February 1955, including a class experiment (effects of drugs on isolated rabbit intestine), and demonstrations (effects of acetylcholine and other drugs in the anaesthetized cat, effects of acetylcholine and other drugs on the clam heart, and Langendorff heart preparation).

A paper from January 1955 titled, "effects of drugs on the cardio-vascular system"

A description of the composition of the class on 2 March 1955, including a class experiment (determination of mydriatic activity in mice), and a demonstration (the peristaltic reflex of the guinea-pig ileum).

A description of the composition of the class on 9 March 1955, including a class experiment (effect of drugs on the frog rectus preparation), and demonstrations (the cat sciatic gastrocnemius preparation, and paralysis in chicks).

A description of the composition of the class on 16 March 1955, including class experiments (continuation of frog rectus preparation and rabbit's auricles preparation), and demonstrations (the rat diaphragm preparation, and methods for studying hydrolysis by cholinesterases).