Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle.

  • Meyer, Hans (Hans Johannes Leopold), 1871-
Date:
1903
Catalogue details

Licence: In copyright

Credit: Determination of radicles in carbon compounds / by Dr. H. Meyer. Authorized translation by J. Bishop Tingle. Source: Wellcome Collection.

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    necessary to resort to one of the other forms of pro- cedure in order to determine the Constitution of the body under investigation. As the groups Nil, NII2 and SH are all capable of acylation, care is required to avoid confusion.if the original compound contains nitro- gen or sulphur. Instances are known of acetylation taking place in the absence of hydroxyl and of the groups just referred to, thus diacetylhydroquinol is formed from quinone, acetic anhydride, and sodium acetate •/tetrachloroquinone and acetyl chloride yield diacetyltetrachlorohydroquinol.1 2 Acetylating reagents frequently cause isomerization or polymerization, and sometimes lead to the production of anhydrides, etc. ; thus benzhydrylacetocarboxylic anhydride is obtained from the isomeric orthocinnamocarboxylic acid by the action of acetic anhydride and sodium acetate,3 and isocantharidin is produced from cantharic acid when heated in a sealed tube vvith acetyl chloride.4 In view of these and similar facts, care should be taken to hydrolyse the presumptive acetyl derivative and identify the product with the original substance; should this not be possible, then proof must be obtained tliat the derivative does actually contain the acid radicle, the introduction of which has been attempted. 1 Sarauw, B. 12, 680. 2 Graebe, Arm. 146, 13. 3 Benedikt and Ehrlich, M. 9, 529. 4 Anderlini and Ghiro, B. 24, 1998. Cf. Pinner B. 27 (1894), 2861; 28 (1895), 456.