A manual of animal vaccination : preceded by considerations on vaccination in general / by E. Warlomont ; translated and edited by Arthur J. Harries.

Date:
1885
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Licence: Public Domain Mark

Credit: A manual of animal vaccination : preceded by considerations on vaccination in general / by E. Warlomont ; translated and edited by Arthur J. Harries. Source: Wellcome Collection.

Provider: This material has been provided by the Royal College of Physicians of Edinburgh. The original may be consulted at the Royal College of Physicians of Edinburgh.

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    attributing it to the intensity of the microbiotxc action The nuclei are broken up, the cells become indistinct and develop into diffused masses, structureless and tinged with yellow (primary necrosis). The description by Pm- cus is similar to that given by Weigert of the smal - pox eruption, and disposes of that furnished by French authors. . Whatever may be the nature of this prehmmary change in the epidermic cells, it is proved that the micro- cocci multiply in the neighbourhood of these foci mth extreme rapidity. The second zone, less acutely affected by the virus, is denominated by Pincus the zone of mild degeneration {zone de cUcjenerescence trouble). The third, outside, is that of irritation : the cellular growth here seems to be very active. As we have said, the shght injury (to the tissues) in- duces almost immediately a congestive reaction, with increase in the sanguineous and lymphatic circulation. This ordinary period of reaction is very short, and is generally followed on the second day by a marked dimi- nution in the activity of the plasmic coincidents. The consequent rest lasts from twenty-four to forty-eight hours. This depression of the circulation is attributed by the author to the extreme local irritation; it is accom- panied by a rapid multiplication of the microbes. Between the third and fourth days the protoplasmic increase generally becomes very active, though Ave do not at present know the reason of this change. It is now that the development of the vesicle begins. Serum makes its way into the zone of inoculation and into that of dull degeneration; the outside zone increases in size, cellular multiplication is still active in it. At