Recent advances in endocrinology / by A.T. Cameron.

  • Cameron, A. T. (Alexander Thomas), 1882-1947.
Date:
1935
Catalogue details

Licence: In copyright

Credit: Recent advances in endocrinology / by A.T. Cameron. Source: Wellcome Collection.

    92/444 (page 78)
    manifestations, a fall in pulse and basal metabolism, and a histological change in the thyroid gland in the direction of increase in colloid and decrease in vascularity and epithelial hypertrophy.” The effect can be produced at any stage of the disease, provided the patient has not recently received iodine. The higher the initial rate, the greater is the resulting Fig. 4.—Response to iodine in Graves’ disease. The average basal metabolism before is compared with that after the usual course of iodine in the form of Lugol’s solution. The abscissae represent the average time required for the characteristic response. A total of 128 eases was divided into groups according to the pre-iodine metabolic rates, each ten-point rise defining a group. (From Means. Thompson, and Thompson, Trans. Assoc. Am. Physicians, 1928, xliii, 146.) fall ; this is well shown in Fig. 4. If the treatment is stopped, the basal metabolic rate rises abruptly. While, in the majority of cases of Graves’ disease, thyroidectomy apparently effects a cure, yet “ in certain eases the disease smoulders on even after this operative procedure, and certain residual phenomena yielding to iodine are not infrequently encountered.” An example of such a ease is