The malarial fevers of Baltimore : An analysis of 616 cases of malarial fever, with special reference to the relations existing between different types of haematozoa and different types of fever / by William Sydney Thayer and John Hewetson.

  • Thayer, William Sydney, 1864-1932.
Date:
1895
Catalogue details

Licence: Public Domain Mark

Credit: The malarial fevers of Baltimore : An analysis of 616 cases of malarial fever, with special reference to the relations existing between different types of haematozoa and different types of fever / by William Sydney Thayer and John Hewetson. Source: Wellcome Collection.

Provider: This material has been provided by the Augustus C. Long Health Sciences Library at Columbia University and Columbia University Libraries/Information Services, through the Medical Heritage Library. The original may be consulted at the the Augustus C. Long Health Sciences Library at Columbia University and Columbia University.

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    be seen—reproductive forms—but also at the time when degenera- tive processes — vacuolization, fragmentation—were most common. In one instance a flagellate body was seen during apyrexia, at a time when only occasional large swollen forms were seen, beyond the half developed forms within the red corpuscles, from which we have never seen flagellate bodies develop. The tertian flagellate bodies were materially larger than the quartan forms which resembled much more, the flagellate bodies in aestivo-autumnal infection. We have seen nothing which would lead us to believe that the development of flagellate bodies in aestivo-autumnal fever had any connection whatever with the paroxysm. On the other hand, in the majority of cases these forms were noted after the paroxysms had ceased, when the temperature was entirely normal. In 6* of the 18 cases of aestivo-autumnal fever quinine had been previously administered, and in seven of these instances flagellate bodies were observed for days after the fever had entirely disappeared. These statistics give us little particularly definite, then, with regard to the nature of the bodies. Their apj)earance, their activity, the regularity of outline, the shape of the flagella are very much against their being com- pared to the sarcodic prolongations of degenerating red corpuscles, which are certainly very dissimilar in appearance. Their occurrence in tertian and quartan fevers, generally in association with segmenting forms at the time of the paroxysm, might lead us to lean toward the opinion of Dock and Maunaberg, that they represent a reproductive process difieriug from that which usually takes place. On the other hand, the arguments of Bignami, Bastianelli, Marchiafava, Celli and others, who call attention to the fact that, in tertian fever, the flagella develop, regularly, from the large, swollen forms which otherwise end, apparently, only in vacuolization and fragmentation, and draw so interesting an analogy between these forms and the cresceutic, ovoid, and round bodies, from which the flagella develop in aestivo-autumnal infections, have, also, much to say in their favor. The most suggestive point in our analyses is, it appears to us, that concerning the time at which the flagellate bodies in aestivo- autumnal infections appear. In an half of the cases the paroxysms *In both of the two additional instances in the dispensary where flagellate bodie were noted, quinine had been previously administered.