Immunological relations of a chicken sarcoma / Wm. H. Woglom.

  • Woglom, William Henry, 1879-1953.
Date:
1914
Catalogue details

Licence: In copyright

Credit: Immunological relations of a chicken sarcoma / Wm. H. Woglom. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    On the other hand, the observation that some of the fowls engrafted with the sarcoma thirty-two and forty days after treatment, had smaller tumors than did those in the corresponding control groups, suggests that it may be possible, after all, to pro- duce immunity to this growth, though it is evident that the de- velopment of the refractory state would take much longer than the ten days requisite in the mouse. It is intended to continue the experiment as soon as fertile eggs can be obtained in sufficient number. TABLE I Interval Between Treatment and Tumor ] noculation Dose of Embryo Emulsion Number of Chickens Tumors , No bum or s 5 days 5.0 C.C. 8 treated, 10 controls1 10 O 5 3 5 days 10.0 C.C. 6 treated, 6 controls 6 O 6 0 io days 1.0 C.C. 17 treated, 15 controls 15 0 • 16 I 12 days 5.0 C.C. 10 treated, 11 controls 11 0 10 0 14 days 2.0 C.C. 9 treated, 5 controls 5 0 9 0 14 days 4.0 C.C. 5 treated, 2 controls 2 0 5 0 25 days 5.0 C.C. 11 treated, 10 controls1 10 0 10 I 28 days 2.0 C.C. 3 treated, 3 controls 3 0 3 0 32 days 5.0 C.C. 3 treated, 5 controls 5 0 2- 1 40 days 5.0 C.C. 7 treated, 11 controls 11 0 O 7 0 Even though it be finally proved impossible to immunize chickens against this tumor, the observation would lie no un- answerable argument against its sarcomatous nature, for, in the first place, it is not known that the immunological reactions char- acteristic of the mouse have their counterpart in the chicken, and, secondly, mouse tumors are occasionally found against which no resistance can be produced. It could be interpreted, at best, only in conjunction with such facts as have been already ascertained, or as may be discovered in the future. 1 Same controls used for both experiments. 2 More small tumors than among controls.