Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell.

  • Russell, B.R.G.
Date:
1910
Catalogue details

Licence: In copyright

Credit: Sarcoma development occurring during the propagation of a haemorrhagic adeno-carcinoma of the mamma of the mouse / by B.R.G. Russell. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    manner described by Haaland and then transplanted. Here it was found that the change had gone much further. Nearly the whole of one end of the tumour was pure spindle-celled sarcoma, whilst the other end, excepting one or two small bands of sarcoma, was carcino- matous. From series 9a another tumour, set. 55 days, had also been transplanted, giving series 10c. Although fifty-five days had elapsed since the introduction of the graft which gave rise to this tumour, macroscopical evidence of growth could only be detected during the latter forty-two days. No evidence of a sarcomatous transformation of the stroma was detectable in this tumour. From 10c a tumour was transplanted giving 11b; this tumour was also a pure carcinoma. Three tumours of 11b were examined and transplanted,—one, a pure carcinoma fet. 33 days, gave 12b, and the two other tumours which already exhibited the sarcomatous changes gave 12e and 12f. The ages of the latter tumours were 63 and 76 days respectively. Thus far there had been examined four tumours showing sarcoma development, and varying in age from 63 to 85 days. None of their parent tumours, all of which had remained pure carcinomata, had ever grown in any single mouse for such a long time. It appeared, there- fore, as if long residence in one animal played a part in producing this peculiar change in the stroma of the tumours. To prove if this were the case or not, the attempt was made to retain the tumours in one animal for a long period, either by choosing somewhat larger mice, or by partially excising the tumour when it had attained to a large size and was threatening to destroy the mouse through ulceration of the overlying skin. A large tumour of lOc, number 9, was chosen for operation. At the time of the operation 109 clays had elapsed since the date of inoculation, but no palpable growth had been formed until thirty days before the operation. A frozen section of this tumour was examined about three hours after the operation, and found to be pm-e carcinoma. The rest of the tumour which had been kept in the ice chest was then transplanted into twenty mice giving series 11c. Three weeks later a second operation was performed on the recurrent tumour, and a small tongue of sarcomatous looking tissue was found at one side of the tumour, and a second small area in the centre as seen in Fig. F. INfaterial from this operation was not transplanted and is not represented in Fig. D. Seven weeks later the mouse was killed and the distribution of the sarcomatous and carcinomatous areas in the second recur- rence is given in Fig. G. Material from the autojisy was transplanted into series llo, and gave in the daughter tumours a pure sarcoma with irregular shaped cells, but generally spindle-shaped in contour. A third tumour of series 10c presented a very peculiar type of growth. The tumour grew pro- gressively for the first five weeks after inoculation, and then diminished to a small nodule, which thereafter varied in size for a few months and finally began to grov/ rapidly. The resulting tumour was excised 202 days after inoculation, and was found to be a pure spindle-celled sarcoma. Two daughter tumours developed in series 1 Ic, and both were examined previous to transplantation. One at forty-eight days remained pure carcinoma, and was transplanted, giving series 12g. The second, at eighty days, showed