Factors affecting the coagulation time of blood. VI, The effect of rapid progressive hemorrhage upon the factors of coagulation / by Katherine R. Drinker and Cecil K. Drinker from the Laboratory of physiology in the Harvard Medical School and the Medical Clinic of the Peter Bent Brigham Hospital, Boston.

  • Drinker, Katherine R.
Date:
1915
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Licence: In copyright

Credit: Factors affecting the coagulation time of blood. VI, The effect of rapid progressive hemorrhage upon the factors of coagulation / by Katherine R. Drinker and Cecil K. Drinker from the Laboratory of physiology in the Harvard Medical School and the Medical Clinic of the Peter Bent Brigham Hospital, Boston. Source: Wellcome Collection.

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    TABLE 1 CAT RABBIT Percentage decrease in coagulation time Percentage decrease in antithrombin Percentage decrease in coagulation time Percentage decrease in antithrombin Jc per cent per cent per cent per cent 2d specimen. 11.1 15.1 5.4 6.7 3d specimen. 15.4 30.9 17.8 23.6 4th specimen. 25.0 26.4 24.8 25.9 5th specimen. 27.0 34.6 31.6 30.8 6th specimen. 37.4 No specimen 32.2 34.7 ' obtained Table 2 gives a summary of the results obtained in our entire series of experiments. DISCUSSION AND CONCLUSIONS Coagulation Time. Our experiments, in accord with the observations of other investigators, show that rapid progressive hemorrhage causes a decrease in coagulation time. An occasional: animal proves an exception to this rule, and shows practically no change in its rate of clotting no matter how severe the hemor¬ rhage (e.g., Exps. II and XI in Table 2), but the majority of the animals show a gradual steady fall in the rate of coagulation as the hemorrhage proceeds. Antithrombin. In our series of experiments, the decrease in coagulation time is accompanied by a decrease in the amount of anti thrombin. Whether or not this change is the result of a simple dilution of the blood by an influx of fluid from the tissues, or whether it is due to a decrease in the amount of anti thrombin formed, we are unable to say. In either case the fact of diminu¬ tion remains. Gray and Lunt12 have shown that there is no decrease in coagulation time after hemorrhage in. an anterior animal (i.e. an animal in which the aorta and vena cava are li¬ gated just above the diaphragm). This observation may be easily reconciled with our experiments. If the decrease in antithrombin 12 Gray and Lunt: Loc. Cit. (1).
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