Round-celled sarcoma of the anterior mediastinum : extensive metastasis, including the brain, both choroid coats, oculo-motor and optic nerves, and external ocular muscles / by Arthur V. Meigs and G. E. De Schweinitz.

  • Meigs, Arthur V. (Arthur Vincent), 1850-1912.
Date:
[1894]
Catalogue details

Licence: Public Domain Mark

Credit: Round-celled sarcoma of the anterior mediastinum : extensive metastasis, including the brain, both choroid coats, oculo-motor and optic nerves, and external ocular muscles / by Arthur V. Meigs and G. E. De Schweinitz. Source: Wellcome Collection.

Provider: This material has been provided by UCL Library Services. The original may be consulted at UCL (University College London)

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    teristics. Here the normal constitution ceases, and the nerve bundles, and in many places the individual fibres, are separated by collections of round sarcoma cells, which have closely followed the connective-tissue septa and the bloodvessels supported by them. In other words, instead of the ordinary membranous investment of the fasciculi, this has been changed into one composed of the cellular elements of the sarcoma. In the right oculo motor nerve precisely the same process is repeated, only the infiltration of the perineurium and endoneurium is so extensive that the appearance is that of a section of ordinary round-celled sarcoma, through Fig.i. Section of right oculo-motor nerve showing extensive sarcoma-infiltration. which are interspersed here and there single, normally constituted nerve fibres. (Fig. 1.) Portion of the posterior half of the right eyeball and 9 mm. of the optic nerve in longitudinal section. Beginning from the extra-ocular end of the optic nerve and passing to the lamina cribrosa, there is no marked change in the nerve bundles and no increase in the nuclei. The trabeeulae of connective tissue are more developed than in the normal nerve, but are not infiltrated with sarcoma cells. Toward the extra ocular end of the nerve are several capillary vessels, around which are clustered numerous round cells. The lumen of the central arteries contains a few blood cells, and in addition small collections of larger, deeply stained lymphoid cells—a condition which re-