The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw.

  • Laidlaw, Patrick Playfair, 1881-1940.
Date:
1910
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    somewhat slowly before administration of the drug. In addition the force of the heart-beat is considerably augmented. These two factors are well illustrated in Figures 4 and 5. Fig. 4 shows the effect of 1 mgm. of the alkaloid injected into the perfusion cannula when an isolated cat’s heart was perfused with warm oxygenated Ringer solution according to the Locke-Langendorff131 method. It is noteworthy that the increase in size of the heart-beat is due to an increase in the completeness of systole. Fig. 5 is a cardiometer record of a cat’s heart Fig. 4. Isolated heart of cat, perfused. Record from tip of left ventricle, suspension method, time in seconds. A, normal and first effect of 1 mgr. tetrahydropapaveroline hydrochloride injected into perfusion cannula. B, 1 min. after end of A ; C, 3 mins, after end of B. Fig. 5. Fig. 6. Fig. 5. Cat, pilbed. Cardiometer record by bellows recorder, signal, time in 10. Effect of 8 mgrs. tetrahydropapaveroline hydrochloride. Fig. 6. Isolated heart of rabbit perfused after the Locke-Langendorff method. Record from tip of left ventricle, drop record of coronary outflow, time in seconds. Effect of •5 mgr. tetrahydropapaveroline hydrochloride. 31-3