The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw.

  • Laidlaw, Patrick Playfair, 1881-1940.
Date:
1910
Catalogue details

Licence: Attribution 4.0 International (CC BY 4.0)

Credit: The action of tetrahydropapaveroline hydrochloride / by P.P. Laidlaw. Source: Wellcome Collection.

Provider: This material has been provided by The Royal College of Surgeons of England. The original may be consulted at The Royal College of Surgeons of England.

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    On the urine flow no variation was observed other than a transient diminution probably secondary to the fall of blood-pressure. The ease with which the alkaloid is oxidised seemed to make it probable that it is destroyed in the body. Experiments to determine its excretion or destruction were accordingly not undertaken. Skeletal muscle appears to be unaffected by the alkaloid. No difference in response either in the irritability of a nerve-muscle preparation or the form of its contraction could be demonstrated as a result of soaking in Ringer’s solution containing tetrahydro- papaveroline hydrochloride to the extent of 1 part in 1000. REFERENCES. (1) Pyman. Trans. Chem. Soc. xcv. p. 1610. 1909. (2) Brodie and Dixon. Journ. of Physiol, xxix. p. 97. 1903. (3) Locke and Rosenheim. Journ. of Physiol, xxxvi. p. 205. 1907-8. Locke. Centr. fur Physiol, xix. p. 737. 1905. (4) Dixon. Proc. Physiol. Soc. p. xxvi, Journ of Physiol, xxxv. 1907.