The physiological effects of peptone and its precursors when introduced into the circulation : interim report ... / E.A. Schäfer [and others].

  • Sharpey-Schäfer, E. A. (Edward Albert), Sir, 1850-1935.
Date:
[1898]
Catalogue details

Licence: Public Domain Mark

Credit: The physiological effects of peptone and its precursors when introduced into the circulation : interim report ... / E.A. Schäfer [and others]. Source: Wellcome Collection.

Provider: This material has been provided by The University of Glasgow Library. The original may be consulted at The University of Glasgow Library.

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    the paper before referred to, concerning Witte's peptone.1 It was then found that this substance, in doses of (H grm. per kilo, retards coagula- tion almost invariably, and the same effect was observed to be the rule with doses as low as one-fifth this quantity. Grosjean2 had also found coagulation to be delayed from one to ten hours by propeptone in doses of 0-l grm. per kilo. Below 0-02 grm. per kilo a hastening of blood-coagu- lation was the rule. The result, however, is corroborated by those of Spiro and Ellinger,3 published during the course of this research. These observers found a reduction of coagulation-time from eight to four minutes with a dose of 0-6 grm. per kilo. With regard to former investigators, it is to be remarked that Pollitzer4 did not find that anti-peptone (tryptone) produced any effect on the rapidity of coagulation, agreeing in this with Pano.5 It is pro- bable that neither of these experimenters used very pure products. Nor can the hastening effect of Witte's peptone on blood-coagulation, in small doses, be attributed solely to an admixture with anti-peptone, since deutero-albumose in certain doses, as will be shown later, has been found to hasten this process, while in other doses coagulation is markedly retarded. (b) On blood-pressure.—Pollitzer evidently had noted that the effect of anti-peptone (tryptone) on blood-pressure was different from that of albumoses, since he makes an exception of it, stating that its effect is doubtful. In the present research it has been found that anti-peptone in its action on blood-pressure likewise contrasts with other products of proteid digestion. In doses of 0 2 grm. per kilo, after a very tran- sient fall immediately following the injection, blood-pressure returns to a level, as a rule, somewhat higher than before the injection. This was ob- served also in one of two experiments with doses of 0-3 grm. per kilo each. In the other, the fall lasted somewhat longer, but even here the duration of lowered blood-pressure was very temporary when compared with that of Witte's peptone, minutes as compared with hours. _ Spiro and Ellinger 6 also state that they have found essential differences in the effects of this substance, amongst other things, on blood-pressure as contrasted with albumoses. They, however, reserve their results for future publication. It is interesting, as these observers point out, to note the contrast of this substance with that of the albumoses, out of which it arises in view of the possibility that toxins and anti-toxins are similarly related as to origin. (c) On peripheral vaso-motor irritability.—As might be anticipated, this substance was not found to possess any depressing action on the tone ot blood-vessels, either abdominal or general. On the contrary, in many cases a decided increase of irritability was shown 1 Thompson, op. cit. ,h, L?T°Tan' 'L>?fcio° Physiologique de la propeptone et de la peptone' Traraur (hi laboratmrc de Leon Friderioq, tome iv. 1891-92 p 45 peprone, irataua 1;(1 xxiH?(1897), Hft 2, p !m 7/W'-'sV - *> itsoMft f. physioloffUche Chenfie, rf^0^:^!^™^^* Acti0D °f Pcptoncs and Albumoses,' Joum. Afli^^Zjl^l^ Pept0DS und «« Blut u. Lymphe' 6 Spiro and Ellinger, op. oit.