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C3bot1 toxin from Clostridium botulinum

  • K R Acharya
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Credit: C3bot1 toxin from Clostridium botulinum. K R Acharya. Attribution 4.0 International (CC BY 4.0)

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Molecular model of C3 exoenzyme from Clostridium botulinum (C3bot1) binding to its substrate NAD (gold). Its enzymatic action cleaves the cofactor NAD which interferes with the normal regulation of many cell pathways through Rho GTPases. It can stimulate regeneration of injured axons making it a potential treatment for certain neural disorders


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