Studies of nitrogen partition in the blood and spinal fluid, with especial reference to the possible causation of albuminuric retinitis / Alan C. Woods, M.D. Boston.

  • Alan Churchill Woods
Date:
1915
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Licence: In copyright

Credit: Studies of nitrogen partition in the blood and spinal fluid, with especial reference to the possible causation of albuminuric retinitis / Alan C. Woods, M.D. Boston. Source: Wellcome Collection.

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    nitrogen as an average of 91.2 per cent, of the total nonprotein nitro¬ gen. The highest total nonprotein nitrogen he reported was 289 mg. per hundred c.c. of blood in a case of mercury poisoning. Agnew14 in 1914 reports a series of estimations of total nonprotein nitrogen and urea nitrogen. The more recent work on the subject of nitrogen partition has been done by Folin and his co-workers. In 1913, Folin and Denis15 reported on the determination of nitrogenous waste products, and stated that they had found no particular diagnosis to correspond with any particu¬ lar degree of nitrogen retention. At the same time Seymour10 reported a series of determinations of total nonprotein nitrogen, urea nitrogen, and uric acid in the blood. In 1914, Folin and Denis17 reported further on the influence of diet on these same nitrogenous bodies. Again in 1914, Folin and Denis18 reported a series of twenty-seven estimations of the total nonprotein nitrogen, ammonia nitrogen, uric acid, creatinin, and combined creatinin and creatin, in cases both of health and disease. In four estimations on healthy individuals, the total nonprotein nitrogen varied from 24 to 37 mg. per hundred c.c. of blood, urea nitrogen from 11 to 18 mg.; ammonia nitrogen from 0.1 to 0.14 mg.; uric acid from 2 to 3 mg.; creatinin from 1.1 to 1.3 mg. and combined creatinin and creatin from 6.5 to 9.5 mg. per hundred c.c. of blood. In pathologic conditions, figures were found as high as 326 mg. for the total non¬ protein nitrogen in a case of decompensated cardiorenal disease. In uremia the highest figures found for the various nitrogenous bodies were, total nonprotein nitrogen 264 mg., urea nitrogen 228 mg., ammo¬ nia nitrogen 0.66 mg., uric acid 6.6 mg., creatinin 26 mg., and com¬ bined creatinin and creatin 46 mg., all per hundred c.c. of blood. In 1915 Foster19 reported he had found substantially the same figures in 14. Agnew, J. Howard: Comparative Study of Phenolsulphonephthalein Elimination, and the Incoagulable Nitrogen in the Blood in Cardiorenal Diseases, The Archives Int. Med., 1914, xiii, 485. 15. Folin, Otto, and Denis, W.: Nitrogenous Waste Products in the Blood in Nephritis, Their Significance and the Methods of Determination, Medical Communications, Massachusetts Med. Soc., 1913, xxiv, 157. 16. Seymour: Nitrogenous Waste Products in the Blood, Their Effect in Chronic Interstitial Nephritis, Medical Communications, Massachusetts Med. Soc., 1913, xxiv, 163. 17. Folin, Otto, Denis, W., and Seymour, Malcolm: The Nonprotein Nitrog¬ enous Constituents of the Blood in Chronic Vascular Nephritis (Arteriosclero¬ sis) as Influenced by the Level of Protein Metabolism, The Archives Int. Med., 1914, xiii, 224. 18. Folin, Otto, and Denis, W.: On the Creatinin and Creatin Content of Blood, Jour. Biol. Chem., 1914, xvii, 487. 19. Foster, Nellis B.: Uremia. The Nonprotein Nitrogen of Blood, The Archives Int. Med., 1915, xv, 356.
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